{"id":"W3154248475","doi":"10.1016/j.jhep.2021.03.029","title":"Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis","year":2021,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Medical Research Council; Fonds Wetenschappelijk Onderzoek; Austrian Science Fund; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Vlaamse regering; Deutsche Krebshilfe; European Commission; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Pathogenesis; Downregulation and upregulation; Primary sclerosing cholangitis; Medicine; Cancer research; Gastroenterology; Pathology; Biology; Gene; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257204,0.0003375996,0.0003018142,0.0004823361,0.0002755099,0.0005686911,0.0001958886,0.0004852416,0.002021969],"category_scores_gemma":[0.0001839983,0.0001914669,0.0003508847,0.0002350919,0.0003287776,0.0002242117,0.0003494308,0.000676535,0.0005203952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831187,"about_ca_system_score_gemma":0.0001920436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000543507,"about_ca_topic_score_gemma":0.0006350456,"domain_scores_codex":[0.9996681,0.00008325101,0.00002659127,0.0000393555,0.00008595055,0.00009680746],"domain_scores_gemma":[0.9998806,0.000009579303,0.00004276364,0.00001249269,0.000017816,0.00003679298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005639715,0.00004187139,0.006885538,0.0002257075,0.00003719363,0.0008390746,0.00006345611,0.0001294954,0.984999,0.0003944499,0.0003688911,0.005451269],"study_design_scores_gemma":[0.000140571,0.001210332,0.3476862,0.0001316192,0.0003713092,0.008279148,0.00134422,0.004700639,0.6161692,0.0009463761,0.01898176,0.00003872755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908161,0.005468396,0.001232085,0.0003265659,0.00005696738,0.00001293296,0.0001705159,0.0000891767,0.001827239],"genre_scores_gemma":[0.9975503,0.0008323274,0.0003336517,0.00009132967,0.00001879901,0.000005854964,0.0001599162,0.000005888541,0.001001848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021969,"threshold_uncertainty_score":0.006764174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577189844611659,"score_gpt":0.2575338130720999,"score_spread":0.2417619146259833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}