{"id":"W3154302966","doi":"10.1093/braincomms/fcab073","title":"Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals","year":2021,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University Health Centre; McGill University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Servier; European Commission; Hjärnfonden; Vetenskapsrådet; Eisai; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; University of Southern California; University College London; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Northern California Institute for Research and Education; Pfizer; BioClinica; Biogen; BrightFocus Foundation; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; H2020 European Research Council; Gun och Bertil Stohnes Stiftelse; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Fluorodeoxyglucose; Internal medicine; Pittsburgh compound B; Cognitive decline; Oncology; Amyloid (mycology); Alzheimer's Disease Neuroimaging Initiative; Medicine; Cohort; Disease; Neuroimaging; Alzheimer's disease; Apolipoprotein E; Psychology; Endocrinology; Positron emission tomography; Pathology; Neuroscience; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246058,0.0003489697,0.0003089033,0.0006468015,0.0003309699,0.0004394679,0.0002161346,0.0004919284,0.001597398],"category_scores_gemma":[0.0009614739,0.0003401696,0.0002627043,0.0005159491,0.0002028972,0.0002254688,0.0002456712,0.0004511994,0.000218311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307697,"about_ca_system_score_gemma":0.00008735493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002122322,"about_ca_topic_score_gemma":0.001716544,"domain_scores_codex":[0.9999045,0.00001718978,0.00001164146,0.00003103739,0.00001785245,0.00001771648],"domain_scores_gemma":[0.9994351,0.00009839804,0.0002664862,0.00004725321,0.00004870783,0.0001039948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000675988,0.0000625359,0.9954041,0.000009974207,0.000117381,0.0002102434,0.0001025848,0.00006044262,0.002228368,0.00001545533,0.00006739467,0.001045528],"study_design_scores_gemma":[0.00000601766,0.0000738286,0.9993299,0.000001382807,0.00001868692,0.000276733,0.00003659158,0.00009831182,0.0001076916,0.0000171649,0.00003225514,0.000001454008],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997079,0.00007494036,0.00002857248,0.000008895099,0.000001814267,0.000001247601,0.00008530582,0.000001725205,0.00008967178],"genre_scores_gemma":[0.9996459,0.00003626306,0.00005171756,0.000008512309,0.000004487148,0.000002384327,0.0001347132,0.000001148657,0.0001148819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002122322,"threshold_uncertainty_score":0.005343854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03778502937512834,"score_gpt":0.3079102558838996,"score_spread":0.2701252265087713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}