{"id":"W3154416445","doi":"10.1089/hum.2020.301","title":"Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey Central Nervous System","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia; BC Children's Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Transgene; Woodchuck hepatitis virus; Central nervous system; Neuropil; Adeno-associated virus; Viral vector; Synapsin; Virology; Striatum; Molecular biology; Cell biology; Green fluorescent protein; Neuron; Neuroscience; Vector (molecular biology); Virus; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004393483,0.0007843318,0.0005260292,0.0009882348,0.0003085248,0.0005348912,0.0004294344,0.0005584421,0.001520399],"category_scores_gemma":[0.0001617417,0.0003671206,0.0003786175,0.0003862147,0.0006032644,0.0003484162,0.0003335614,0.00102038,0.0009692897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004374251,"about_ca_system_score_gemma":0.0005224917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00166861,"about_ca_topic_score_gemma":0.00243644,"domain_scores_codex":[0.9995073,0.00005322394,0.0000471239,0.000200292,0.00009855458,0.00009351396],"domain_scores_gemma":[0.9997858,0.00002305014,0.00005473235,0.00003322845,0.00002880017,0.00007431576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005192311,0.0000301272,0.00009567688,0.00002250775,0.000006077873,0.00005020403,0.00003462138,0.00002120866,0.9987619,0.00008205957,0.00004679647,0.0007969557],"study_design_scores_gemma":[0.00003457261,0.0006527664,0.005381383,0.00002467511,0.00003849045,0.000457457,0.00005011864,0.0007210769,0.9878011,0.0001192202,0.00470657,0.00001250375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661338,0.003177406,0.02014405,0.0002217428,0.0001371611,0.0003298174,0.001778931,0.001069648,0.007007378],"genre_scores_gemma":[0.9449322,0.003676835,0.02972239,0.0002607959,0.0000627047,0.000793974,0.003171389,0.0004521641,0.01692749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166861,"threshold_uncertainty_score":0.005086243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276084136575505,"score_gpt":0.2830117269109717,"score_spread":0.2702508855452166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}