{"id":"W3154416445","doi":"10.1089/hum.2020.301","title":"Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey Central Nervous System","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia; BC Children's Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Transgene; Woodchuck hepatitis virus; Central nervous system; Neuropil; Adeno-associated virus; Viral vector; Synapsin; Virology; Striatum; Molecular biology; Cell biology; Green fluorescent protein; Neuron; Neuroscience; Vector (molecular biology); Virus; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362388,0.0001447361,0.0001541425,0.00003264132,0.00006033136,0.00002843918,0.0001361716,0.000111917,0.000009291814],"category_scores_gemma":[0.000007973731,0.0001164221,0.00006282232,0.00008280425,0.00003320602,0.000004531812,0.00002131793,0.00007860292,2.990823e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009713583,"about_ca_system_score_gemma":0.00003605075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001645783,"about_ca_topic_score_gemma":0.00004066451,"domain_scores_codex":[0.9990695,0.0001025422,0.0002469194,0.0002552555,0.00013271,0.0001931327],"domain_scores_gemma":[0.9995422,0.00001114936,0.00005949192,0.0003019281,0.00003931952,0.00004589766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005646149,0.00008221641,0.0004006792,0.00004415718,0.00002564933,0.00002165862,0.0004695324,0.0004715541,0.9961857,0.00004044133,0.00004488713,0.002157092],"study_design_scores_gemma":[0.0006316707,0.0002186976,0.01232619,0.00002929347,0.00000982349,0.0000755711,0.0004883957,0.00005179337,0.98567,0.00001433716,0.0003548709,0.0001293145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920081,0.005968209,0.001633887,0.00004533047,0.00005336131,0.0002034028,0.0000113637,0.000009638653,0.00006664015],"genre_scores_gemma":[0.9983658,0.0009833855,0.0003080016,0.00004266694,0.0001252903,0.00002171345,0.00009811551,0.00001801748,0.00003702831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01192551,"threshold_uncertainty_score":0.4747554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276084136575505,"score_gpt":0.2830117269109717,"score_spread":0.2702508855452166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}