{"id":"W3154491878","doi":"","title":"Safety and tolerability of Fingolimod in Latin american patients with relapsing-remitting multiple sclerosis: the open-label FIRST LATAM study.","year":2015,"lang":"en","type":"article","venue":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"","keywords":"Fingolimod; Tolerability; Medicine; Adverse effect; Discontinuation; Internal medicine; Multiple sclerosis; Expanded Disability Status Scale; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008539117,0.0004625745,0.0008048824,0.0002119466,0.0002953331,0.0005356731,0.0002411799,0.0004844432,0.002143583],"category_scores_gemma":[0.0007943847,0.0002198045,0.000642664,0.0003164125,0.0003335382,0.0004153371,0.0002777067,0.0007439113,0.0004455201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004822295,"about_ca_system_score_gemma":0.0007626288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694834,"about_ca_topic_score_gemma":0.002295485,"domain_scores_codex":[0.999819,0.00008610071,0.00001182929,0.0000271,0.00002505626,0.00003101255],"domain_scores_gemma":[0.9995248,0.00007385905,0.0001700995,0.0000336172,0.00004992843,0.0001476534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5255155,0.02563599,0.2446541,0.0007053777,0.003044816,0.001028236,0.0008306476,0.0008058494,0.03657252,0.0002230201,0.004507569,0.1564764],"study_design_scores_gemma":[0.1911813,0.1178254,0.672631,0.0001322355,0.002122251,0.0009992141,0.000672407,0.001157021,0.002559152,0.0002969182,0.01033807,0.00008498067],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956009,0.00193483,0.0001284519,0.0002778201,0.00002649476,0.0001695274,0.0006190306,0.00002058592,0.001222369],"genre_scores_gemma":[0.995594,0.001228546,0.0002795004,0.0005839322,0.00008648598,0.0002609062,0.001064483,0.0000126198,0.0008895397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002143583,"threshold_uncertainty_score":0.007171035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417574670216515,"score_gpt":0.2485002088705926,"score_spread":0.2143244621684275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}