{"id":"W3154563477","doi":"10.1158/0008-5472.can-20-3979","title":"mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Renal cell carcinoma; TSC1; MAPK/ERK pathway; Cell growth; Biology; Clear cell; Cell biology; Kinase; Medicine; Signal transduction; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035058,0.0003504182,0.0001846428,0.0003409995,0.000254394,0.0002727617,0.000154783,0.0001937966,0.001387642],"category_scores_gemma":[0.000070823,0.0001547716,0.0003064326,0.0001229084,0.0002284551,0.0001831922,0.0002820586,0.0004543216,0.0004694217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003580932,"about_ca_system_score_gemma":0.0002516156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372656,"about_ca_topic_score_gemma":0.0004679893,"domain_scores_codex":[0.9998591,0.00001938995,0.00001012098,0.00002990594,0.00004349147,0.00003793061],"domain_scores_gemma":[0.9999349,0.000005473599,0.00002408703,0.000005763909,0.000009548994,0.00002018436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152956,0.00002800821,0.0005035342,0.00005724927,0.000005121663,0.0001354993,0.00001257263,0.00007545188,0.9972196,0.0003563957,0.00008903215,0.001402319],"study_design_scores_gemma":[0.00001373885,0.0001564805,0.008733371,0.000007535047,0.00001472059,0.0005167802,0.00003224753,0.001113387,0.9859214,0.0001694652,0.003316349,0.000004544958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882685,0.002192388,0.004300471,0.0002275723,0.00004072908,0.00004449366,0.0005196526,0.0002825778,0.004123583],"genre_scores_gemma":[0.9949202,0.0008517037,0.001721928,0.00003535035,0.00001360867,0.00002790488,0.0002614913,0.00001542477,0.002152427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387642,"threshold_uncertainty_score":0.004642189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09248545803040284,"score_gpt":0.3698855645739209,"score_spread":0.277400106543518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}