{"id":"W3154684060","doi":"10.1089/cell.2020.0075","title":"Investigating Markers of Reprogramming Potential in Somatic Cell Lines Derived from Matched Donors","year":2021,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Zoo; University of Guelph","funders":"","keywords":"Reprogramming; Somatic cell nuclear transfer; Biology; Induced pluripotent stem cell; Somatic cell; Epigenetics; Genetics; Embryonic stem cell; Cell culture; Stem cell; Cell biology; Cell; Embryo; Gene; Blastocyst; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000654556,0.0002870293,0.0004210314,0.0001132624,0.00009690083,0.00009351617,0.0003674977,0.0002792629,0.00003841311],"category_scores_gemma":[0.0004343987,0.0003213075,0.0002480995,0.0004469963,0.0001777871,0.00001273569,0.0004753929,0.0002727567,0.00001152859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003663032,"about_ca_system_score_gemma":0.0001989379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005745714,"about_ca_topic_score_gemma":0.0001256363,"domain_scores_codex":[0.9969797,0.0002383006,0.0007608526,0.0009971054,0.0003942023,0.0006298674],"domain_scores_gemma":[0.9982787,0.0000516191,0.000296872,0.000994639,0.0001909193,0.0001872408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000038619,0.0001660344,0.03795969,0.0002332142,0.00006681142,0.0001772747,0.000178527,0.0002311028,0.9449401,0.000001394665,0.00001435572,0.0159929],"study_design_scores_gemma":[0.0008988947,0.00009633609,0.002549541,0.0001558638,0.00003836611,0.000009760366,0.001538729,0.001310906,0.9924248,0.00009665324,0.0005636539,0.0003164302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992633,0.003843558,0.002546553,0.00007786857,0.0001550986,0.0003930916,0.000006345535,0.00003529091,0.0003091611],"genre_scores_gemma":[0.9660371,0.0001450976,0.03267191,0.00002728333,0.0001544912,0.0000530417,0.0004433739,0.00006504713,0.0004026586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04748478,"threshold_uncertainty_score":0.9999239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369256051825714,"score_gpt":0.2477434880318762,"score_spread":0.2340509275136191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}