{"id":"W3154684060","doi":"10.1089/cell.2020.0075","title":"Investigating Markers of Reprogramming Potential in Somatic Cell Lines Derived from Matched Donors","year":2021,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Zoo; University of Guelph","funders":"","keywords":"Reprogramming; Somatic cell nuclear transfer; Biology; Induced pluripotent stem cell; Somatic cell; Epigenetics; Genetics; Embryonic stem cell; Cell culture; Stem cell; Cell biology; Cell; Embryo; Gene; Blastocyst; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006393194,0.000182018,0.0002100238,0.0005269457,0.0001693764,0.0004110289,0.0001671748,0.0002523513,0.001297801],"category_scores_gemma":[0.000764849,0.00009250145,0.0001785443,0.0005453029,0.0002314129,0.0002090423,0.0001931809,0.0002898551,0.0004167822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972783,"about_ca_system_score_gemma":0.000132448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004504152,"about_ca_topic_score_gemma":0.0005652886,"domain_scores_codex":[0.9995831,0.00008546119,0.00006606889,0.0001238009,0.0001010275,0.00004064785],"domain_scores_gemma":[0.9994683,0.0002115224,0.0001037959,0.00008480417,0.00008967098,0.00004194237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122293,0.00002647025,0.005178111,0.00003148647,0.00001299907,0.00005331536,0.00008207312,0.00008926242,0.9907759,0.0001159138,0.00001592002,0.003506363],"study_design_scores_gemma":[0.00001495435,0.0008215516,0.0958228,0.00001948103,0.00009026926,0.0007398532,0.000270856,0.00101898,0.8973197,0.0002377616,0.003627259,0.0000164019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784681,0.0011269,0.01644902,0.00002648289,0.00003052398,0.0001021996,0.001096108,0.0000378643,0.002662679],"genre_scores_gemma":[0.9861756,0.0008007428,0.008048338,0.00005752831,0.000007901476,0.0001899179,0.002560815,0.00003848143,0.002120716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297801,"threshold_uncertainty_score":0.004341602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369256051825714,"score_gpt":0.2477434880318762,"score_spread":0.2340509275136191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}