{"id":"W3154752287","doi":"10.1016/j.vaccine.2021.03.068","title":"Assessment of the population coverage of an HIV-1 vaccine targeting sequences surrounding the viral protease cleavage sites in Gag, Pol, or all 12 protease cleavage sites","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"University of Manitoba","keywords":"Protease; Cleavage (geology); Virology; Population; Biology; HIV-1 protease; Human immunodeficiency virus (HIV); Lentivirus; Enzyme; Medicine; Viral disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009825877,0.0003389117,0.000277294,0.0002081259,0.0001394618,0.0003702407,0.0002318528,0.0006100118,0.00175392],"category_scores_gemma":[0.001423609,0.0001396608,0.0001672784,0.0001450862,0.0002476429,0.0003271951,0.0002595088,0.0004744608,0.0002574702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438882,"about_ca_system_score_gemma":0.0001988624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009261002,"about_ca_topic_score_gemma":0.0006260793,"domain_scores_codex":[0.9994515,0.0002087436,0.00001700853,0.0001060241,0.000112525,0.0001042612],"domain_scores_gemma":[0.9995258,0.0001939596,0.00005161787,0.00003088388,0.000151635,0.00004611683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002642558,0.0006315584,0.02769544,0.000114915,0.0001642333,0.0001025392,0.0002646604,0.006329428,0.9372024,0.0004882665,0.0003803224,0.02398368],"study_design_scores_gemma":[0.0001873463,0.03337196,0.1473603,0.00003180608,0.00051183,0.001219663,0.000690758,0.0496112,0.7600514,0.0008492373,0.006075853,0.00003859871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956154,0.000238699,0.002493513,0.00005003528,0.000009377442,0.00003207698,0.0002113887,0.00001784017,0.001331761],"genre_scores_gemma":[0.9974818,0.0001108801,0.0009151137,0.00006296902,0.00000920576,0.00005429884,0.0003867346,0.000006017913,0.0009731635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175392,"threshold_uncertainty_score":0.005867481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480192544217762,"score_gpt":0.3098436244045744,"score_spread":0.2850416989623967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}