{"id":"W3154794407","doi":"10.1158/1055-9965.epi-20-1690","title":"Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses","year":2021,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Public Health Ontario; University of Toronto","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Environmental Health Sciences; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Center for Advancing Translational Sciences; Seventh Framework Programme; U.S. Public Health Service; Xunta de Galicia; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Institut National Du Cancer; School of Public Health, Imperial College London; Deutsche Krebshilfe; Michigan Department of Health and Human Services; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Cancer Research Foundation in Northern Sweden; Karolinska Institutet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Cancerfonden; Institut Gustave-Roussy; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; World Health Organization; Wageningen University and Research; Cancer Research UK; Génome Québec; Ligue Contre le Cancer; Federación Española de Enfermedades Raras; Imperial College London; Generalitat de Catalunya; Food Standards Agency; Transcan; University of South Florida; Swedish Cancer Foundation; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Canadian Institutes of Health Research; University Hospitals Bristol NHS Foundation Trust; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Moffitt Cancer Center; Department of Health and Social Care; McGill University; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; U.S. Department of Health and Human Services; Deutsches Krebsforschungszentrum","keywords":"Mendelian randomization; Sex hormone-binding globulin; Colorectal cancer; Testosterone (patch); Medicine; Observational study; Internal medicine; Oncology; Cancer; Hormone; Endocrinology; Physiology; Androgen; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001299649,0.0001687626,0.0007088782,0.0001025929,0.0001734748,0.000004343899,0.00002726575,0.000128921,0.0000434912],"category_scores_gemma":[0.001591866,0.0001386125,0.0001062679,0.0002838057,0.0002896681,0.0001016037,0.00006927386,0.0001224756,4.160426e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002338,"about_ca_system_score_gemma":0.0001530638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003512788,"about_ca_topic_score_gemma":0.0001675258,"domain_scores_codex":[0.9980409,0.000540148,0.0005998465,0.0004975916,0.0001121492,0.000209341],"domain_scores_gemma":[0.9985341,0.0005480571,0.0004709399,0.0001050254,0.0002630284,0.0000788409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005210954,0.00003941915,0.7752059,0.0001071428,0.001331855,0.000004497543,0.0001903323,0.0001134906,0.1952484,0.00003339448,0.0001604231,0.02704406],"study_design_scores_gemma":[0.002980317,0.0001221006,0.9843293,0.0002388434,0.0006729494,0.00003145916,0.0003964756,0.001733225,0.008235529,0.001074574,0.00005179628,0.0001334327],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9361447,0.05949322,0.001693939,0.002032089,0.0001410811,0.0003321275,0.00007816099,0.0000189206,0.00006576395],"genre_scores_gemma":[0.9864119,0.009390522,0.003571018,0.00007387454,0.0001572591,0.00007993408,0.00009608031,0.00001236305,0.0002070467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2091234,"threshold_uncertainty_score":0.5652453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1808176031266283,"score_gpt":0.4249703960233164,"score_spread":0.2441527928966881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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