{"id":"W3154794407","doi":"10.1158/1055-9965.epi-20-1690","title":"Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses","year":2021,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Public Health Ontario; University of Toronto","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Environmental Health Sciences; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Center for Advancing Translational Sciences; Seventh Framework Programme; U.S. Public Health Service; Xunta de Galicia; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Institut National Du Cancer; School of Public Health, Imperial College London; Deutsche Krebshilfe; Michigan Department of Health and Human Services; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Cancer Research Foundation in Northern Sweden; Karolinska Institutet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Cancerfonden; Institut Gustave-Roussy; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; World Health Organization; Wageningen University and Research; Cancer Research UK; Génome Québec; Ligue Contre le Cancer; Federación Española de Enfermedades Raras; Imperial College London; Generalitat de Catalunya; Food Standards Agency; Transcan; University of South Florida; Swedish Cancer Foundation; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Canadian Institutes of Health Research; University Hospitals Bristol NHS Foundation Trust; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Moffitt Cancer Center; Department of Health and Social Care; McGill University; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; U.S. Department of Health and Human Services; Deutsches Krebsforschungszentrum","keywords":"Mendelian randomization; Sex hormone-binding globulin; Colorectal cancer; Testosterone (patch); Medicine; Observational study; Internal medicine; Oncology; Cancer; Hormone; Endocrinology; Physiology; Androgen; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07396918,0.0007908315,0.001558854,0.00110348,0.0004988777,0.0008376681,0.001514911,0.0009936346,0.001547101],"category_scores_gemma":[0.1562635,0.0005242662,0.003032126,0.001882473,0.001098782,0.0005987803,0.0005908253,0.0009323753,0.0001600772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008314395,"about_ca_system_score_gemma":0.001307171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004483695,"about_ca_topic_score_gemma":0.002809397,"domain_scores_codex":[0.8846478,0.1022077,0.003703133,0.004786277,0.004023444,0.0006315612],"domain_scores_gemma":[0.8573629,0.1001126,0.02088144,0.01840442,0.002582781,0.0006559694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02726881,0.0004740545,0.8161949,0.0019183,0.05714708,0.001144536,0.0006673504,0.01286555,0.002730169,0.01310643,0.003505487,0.06297734],"study_design_scores_gemma":[0.01222092,0.008177339,0.6924793,0.0007833407,0.04870443,0.004933354,0.0003719486,0.1599699,0.00416383,0.05624372,0.01157314,0.0003787085],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7941554,0.01129595,0.1857755,0.001546636,0.0002767722,0.00156011,0.002895002,0.0005427764,0.001951947],"genre_scores_gemma":[0.9569373,0.0009668337,0.0397138,0.0003253299,0.00008125472,0.0007617695,0.0009366852,0.00004402345,0.0002330838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07396918,"threshold_uncertainty_score":0.3911911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1808176031266283,"score_gpt":0.4249703960233164,"score_spread":0.2441527928966881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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