{"id":"W3154825605","doi":"10.2139/ssrn.3828195","title":"Microbiome-Driven Tryptophan Metabolism Suppresses Immunity in the Pancreatic Tumor Microenvironment by Activation of the Aryl Hydrocarbon Receptor","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Canada Research Chairs; University Health Network","funders":"","keywords":"Aryl hydrocarbon receptor; Microbiome; Metabolism; Aryl; Immunity; Chemistry; Tumor microenvironment; Tryptophan Metabolism; Receptor; Cancer research; Tryptophan; Medicine; Cell biology; Biology; Biochemistry; Immune system; Immunology; Bioinformatics; Tumor cells; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658899,0.0001916263,0.0002544461,0.0001647861,0.0001223057,0.0003391315,0.000145307,0.0002523972,0.002418398],"category_scores_gemma":[0.0002120028,0.0001238491,0.0002944971,0.000106943,0.0002753251,0.0001529965,0.000341795,0.0007303784,0.00047271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172977,"about_ca_system_score_gemma":0.0003373114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003154309,"about_ca_topic_score_gemma":0.0007161986,"domain_scores_codex":[0.9997845,0.00005365503,0.00001413935,0.00003130166,0.00004094374,0.00007535304],"domain_scores_gemma":[0.9998677,0.00001121235,0.00004937412,0.00001507387,0.00001107472,0.0000456122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00163659,0.000096187,0.001130815,0.00005725366,0.00002022089,0.00007568013,0.00001770278,0.00008625807,0.9915717,0.0001578927,0.0001699233,0.004979833],"study_design_scores_gemma":[0.0003138699,0.003653194,0.05856004,0.00004618913,0.000136738,0.0008055017,0.0003748629,0.002625424,0.9226229,0.0006376754,0.01019883,0.00002477245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954854,0.001495253,0.001152738,0.0002817585,0.00008254404,0.00001250003,0.0001823432,0.00007337525,0.001234071],"genre_scores_gemma":[0.9966832,0.0007080328,0.0005090204,0.00009396783,0.00002337231,0.00001859727,0.0001716056,0.00001504697,0.001777151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002418398,"threshold_uncertainty_score":0.008090377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004195589052359814,"score_gpt":0.1990360935327928,"score_spread":0.194840504480433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}