{"id":"W3154859092","doi":"10.3390/biomedicines9040437","title":"Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"College of Medicine, University of Nebraska Medical Center; University of Nebraska Medical Center","keywords":"Bromodomain; Infectivity; Epigenetics; In vitro; Biology; Virology; Virus; Immunology; Pharmacology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651082,0.000159672,0.0001689535,0.00009930129,0.00006846659,0.00003433368,0.00004128347,0.0001563023,0.000003741052],"category_scores_gemma":[0.0001072859,0.0001358963,0.00002570096,0.0001559622,0.0001804159,0.00001684313,0.00009555741,0.00007815503,0.000001572048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001009548,"about_ca_system_score_gemma":0.00004432921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006035585,"about_ca_topic_score_gemma":0.00003705364,"domain_scores_codex":[0.9990131,0.00008769088,0.000224887,0.0003801101,0.0001190761,0.0001751037],"domain_scores_gemma":[0.9996578,0.000007898109,0.00007336612,0.0001490431,0.00005589087,0.00005598994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008465437,0.00005524243,0.001500794,0.00005116691,0.000007836157,0.00001608144,0.0000503451,4.166886e-8,0.9918628,0.000003653652,0.0007409278,0.005626462],"study_design_scores_gemma":[0.0009118976,0.0001624792,0.003592815,0.0001621066,0.000007319192,0.00007119667,0.00007452175,0.00001634121,0.98832,0.00006607994,0.006456813,0.0001584368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956768,0.003146245,0.00007643893,0.0006284295,0.0001484913,0.0002290721,0.000008074943,0.00001542474,0.00007108818],"genre_scores_gemma":[0.9977932,0.0003824758,0.0008797356,0.0001336684,0.0003492856,0.00004820781,0.0001540231,0.00001484714,0.0002445857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005715886,"threshold_uncertainty_score":0.554169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362624510205587,"score_gpt":0.2658732839612439,"score_spread":0.2522470388591881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}