{"id":"W3154887222","doi":"10.2215/cjn.17561120","title":"Understanding and Overcoming the Challenges Related to Cardiovascular Trials Involving Patients with Kidney Disease","year":2021,"lang":"en","type":"article","venue":"Clinical Journal of the American Society of Nephrology","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Ottawa","funders":"Kawasaki Heavy Industries; Relypsa; Baylor University Medical Center; Idorsia Pharmaceuticals; U.S. Food and Drug Administration; Servier; Institut National de la Santé et de la Recherche Médicale; Université de Lorraine; Fresenius Medical Care North America; Boston Scientific Corporation; Gilead Sciences; American Society of Nephrology; AstraZeneca; Baylor University; Amgen","keywords":"Medicine; Intensive care medicine; Kidney disease; Clinical trial; Nephrology; Disease; Psychological intervention; Family medicine; Internal medicine; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.7382804,0.002459761,0.005262002,0.004132433,0.02319774,0.04674863,0.01492177,0.03443047,0.009942284],"category_scores_gemma":[0.7397377,0.004554083,0.005565728,0.003717457,0.03823555,0.04236461,0.04428501,0.06965543,0.003916853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02038291,"about_ca_system_score_gemma":0.1705488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003971204,"about_ca_topic_score_gemma":0.008684582,"domain_scores_codex":[0.1547448,0.7724368,0.02490893,0.01096255,0.02764428,0.009302599],"domain_scores_gemma":[0.08437739,0.7748355,0.03379757,0.0288366,0.04292724,0.03522564],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001109053,0.001309293,0.009679206,0.01647604,0.001640913,0.002856837,0.2233873,0.005804806,0.002651592,0.1171076,0.2282343,0.3897431],"study_design_scores_gemma":[0.0010969,0.001672977,0.003301134,0.02699113,0.000584265,0.001546235,0.0953004,0.004669916,0.001269242,0.3184262,0.5444592,0.0006824424],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005367138,0.009066272,0.03532084,0.9358917,0.005876485,0.002497413,0.00009617216,0.0002120328,0.005671929],"genre_scores_gemma":[0.1238973,0.01617686,0.1782565,0.6457176,0.01564092,0.01646902,0.0002041214,0.0004970907,0.003140569],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.7382804,"threshold_uncertainty_score":0.3227469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1226655378913259,"score_gpt":0.3491175911799722,"score_spread":0.2264520532886463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}