{"id":"W3154889462","doi":"10.1007/978-1-0716-1197-5_22","title":"Probing Protein–Membrane Interactions and Dynamics Using Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)","year":2021,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Hydrogen–deuterium exchange; Membrane; Chemistry; Mass spectrometry; Phosphatidylinositol; Deuterium; Biophysics; Membrane protein; Biochemistry; Kinase; Chromatography; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004035373,0.0003923695,0.0002368585,0.0002256768,0.0005347963,0.0005964018,0.0003784322,0.0006485955,0.001380649],"category_scores_gemma":[0.0002762783,0.000200917,0.0001544391,0.0002892737,0.0004325476,0.0007675319,0.0003676863,0.0007956992,0.0004170265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140042,"about_ca_system_score_gemma":0.0002079305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005670657,"about_ca_topic_score_gemma":0.0007457258,"domain_scores_codex":[0.999826,0.00001717542,0.000007613411,0.00006586914,0.00005499925,0.00002844372],"domain_scores_gemma":[0.9998796,0.00003865901,0.00002568273,0.00002227418,0.00001567412,0.00001816145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004502507,0.00001535877,0.0003562257,0.00004610969,0.00001344546,0.00003683681,0.00001684739,0.00007281359,0.996397,0.000434754,0.0001931297,0.002372504],"study_design_scores_gemma":[0.00001015869,0.00003421585,0.002673245,0.00000315018,0.0000089452,0.0001879622,0.00002881928,0.00256128,0.9908525,0.0003752989,0.003256073,0.000008329935],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8726161,0.003685223,0.1112657,0.001015136,0.000340763,0.0001075386,0.002219665,0.0007561695,0.007993736],"genre_scores_gemma":[0.9194928,0.003616961,0.07011384,0.0006814366,0.00006654327,0.0001004247,0.001319186,0.00009686997,0.004511951],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001380649,"threshold_uncertainty_score":0.004618764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228014193587089,"score_gpt":0.3668269519124904,"score_spread":0.3440255325537815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}