{"id":"W3154980607","doi":"10.1007/s00401-021-02296-1","title":"TREM2 expression in the brain and biological fluids in prion diseases","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Interreg; Instituto de Salud Carlos III; Hjärnfonden; UK Dementia Research Institute; Vetenskapsrådet; Ministero della Salute; European Regional Development Fund; European Commission; University of Alberta; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Alzheimer's Drug Discovery Foundation; Centres de Recerca de Catalunya; Polarforskningssekretariatet; Ministerio de Ciencia, Innovación y Universidades; Alzheimer Society; EU Joint Programme – Neurodegenerative Disease Research; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Fundació la Marató de TV3","keywords":"TREM2; PRNP; Ectodomain; ADAM10; Receptor; Biology; Microglia; Alzheimer's disease; Immunology; Cerebrospinal fluid; Medicine; Pathology; Disease; Inflammation; Internal medicine; Disintegrin; Prion protein; Metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025265,0.0001541961,0.0001598128,0.00009290839,0.0001291613,0.00010083,0.0002415386,0.00006525409,0.00006415438],"category_scores_gemma":[0.003190425,0.00009802298,0.00003851199,0.0004412496,0.00008874826,0.000157197,0.0001603203,0.0002644031,0.00001456236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007341484,"about_ca_system_score_gemma":0.0000200774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.815299e-7,"about_ca_topic_score_gemma":0.000002510885,"domain_scores_codex":[0.9966796,0.001973265,0.0002752815,0.0006280305,0.0002086447,0.0002351886],"domain_scores_gemma":[0.9987981,0.0007558777,0.00006110207,0.000316443,0.00001305159,0.00005537933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002674731,0.000124712,0.002062502,0.000003362879,5.298746e-8,0.001473215,0.0001537118,0.000007029244,0.9934509,0.00143247,0.0001856268,0.001079653],"study_design_scores_gemma":[0.0006048093,0.0001941472,0.1713231,0.00001444507,0.00000179654,0.000497786,0.00007615564,0.0003618028,0.821896,0.001195934,0.003661368,0.0001726913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927963,0.00006139177,0.00005204211,0.006242815,0.0001277724,0.0002318479,0.000008195983,0.00007231556,0.0004073059],"genre_scores_gemma":[0.9877826,0.0005726102,0.00008292092,0.01139473,0.0000361765,0.00003396341,0.00000540447,0.000009671833,0.00008192398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.171555,"threshold_uncertainty_score":0.3997261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05023382745783826,"score_gpt":0.2736660448888754,"score_spread":0.2234322174310371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}