{"id":"W3154980607","doi":"10.1007/s00401-021-02296-1","title":"TREM2 expression in the brain and biological fluids in prion diseases","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Interreg; Instituto de Salud Carlos III; Hjärnfonden; UK Dementia Research Institute; Vetenskapsrådet; Ministero della Salute; European Regional Development Fund; European Commission; University of Alberta; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Alzheimer's Drug Discovery Foundation; Centres de Recerca de Catalunya; Polarforskningssekretariatet; Ministerio de Ciencia, Innovación y Universidades; Alzheimer Society; EU Joint Programme – Neurodegenerative Disease Research; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Fundació la Marató de TV3","keywords":"TREM2; PRNP; Ectodomain; ADAM10; Receptor; Biology; Microglia; Alzheimer's disease; Immunology; Cerebrospinal fluid; Medicine; Pathology; Disease; Inflammation; Internal medicine; Disintegrin; Prion protein; Metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220449,0.0003002171,0.0002298691,0.001066746,0.0002977758,0.0004193542,0.00008333361,0.0002677176,0.000829966],"category_scores_gemma":[0.0003525329,0.0001678276,0.00015619,0.0003692736,0.0003336043,0.0002914717,0.0002866827,0.0002223795,0.0001948917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422467,"about_ca_system_score_gemma":0.0001368364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004355216,"about_ca_topic_score_gemma":0.0004570059,"domain_scores_codex":[0.9998842,0.00002068699,0.00001431986,0.00003085449,0.00002759498,0.00002222214],"domain_scores_gemma":[0.999869,0.00001527286,0.0000466346,0.000008284899,0.00002859813,0.00003219207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003061452,0.0001085789,0.07882051,0.0002595949,0.00009704925,0.003641135,0.0007356078,0.0001088265,0.901127,0.0001818242,0.0002187312,0.01163967],"study_design_scores_gemma":[0.00004627547,0.0009129692,0.8916437,0.00005527013,0.0001313678,0.01464258,0.0006904249,0.0008871485,0.08827394,0.0004447118,0.002239078,0.00003246122],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972614,0.001626709,0.0003322265,0.00001376376,0.000008536143,0.000008033399,0.0001549123,0.00001556536,0.0005787024],"genre_scores_gemma":[0.9975384,0.0008495486,0.000608746,0.00002078893,0.00002331513,0.00002237074,0.0003308171,0.000005160166,0.0006008924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066746,"threshold_uncertainty_score":0.002776504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05023382745783826,"score_gpt":0.2736660448888754,"score_spread":0.2234322174310371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}