{"id":"W3155038553","doi":"10.1021/acs.accounts.1c00125","title":"2′-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions","year":2021,"lang":"en","type":"review","venue":"Accounts of Chemical Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Aptamer; Oligonucleotide; DNA; RNA; Chemistry; Computational biology; G-quadruplex; RNase H; RNase P; Genetics; Biochemistry; Molecular biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582858,0.0005767522,0.0002274724,0.00024045,0.0001881648,0.0002214261,0.000223282,0.0004785038,0.001256054],"category_scores_gemma":[0.00008755818,0.0001270118,0.0001658413,0.0001344327,0.0002264855,0.0004103543,0.0001877838,0.0004693542,0.0004938652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599437,"about_ca_system_score_gemma":0.000126138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373718,"about_ca_topic_score_gemma":0.0005029817,"domain_scores_codex":[0.9999044,0.00002429767,0.000003175474,0.00002796565,0.000021403,0.00001862393],"domain_scores_gemma":[0.9999647,0.000009751654,0.000009072255,0.000004158373,0.000003674469,0.000008638457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004660864,0.0000113535,0.0001530874,0.00008228518,0.000006703037,0.0000858809,0.00001612006,0.0002658986,0.9839462,0.0007967284,0.0002776863,0.01431146],"study_design_scores_gemma":[0.000007882001,0.0001970643,0.0007539526,0.00001126893,0.00001117888,0.0006096588,0.00001188501,0.001259215,0.9618028,0.0003132244,0.03500631,0.00001565557],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6826515,0.09383097,0.1912259,0.001354582,0.0006243126,0.0001425419,0.001021251,0.001446616,0.0277023],"genre_scores_gemma":[0.9378312,0.01287875,0.04199203,0.0002727999,0.00008212737,0.00007453645,0.0003121244,0.00005637317,0.006500117],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001256054,"threshold_uncertainty_score":0.004201889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07153570971578167,"score_gpt":0.4212958051185819,"score_spread":0.3497600954028003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}