{"id":"W3155054302","doi":"10.3390/cancers13081841","title":"A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Estrogen; In vivo; Estrone; Breast cancer; Ovariectomized rat; Endocrinology; Internal medicine; Cancer research; Menopause; In vitro; Estrogen receptor; Aromatase; Medicine; Chemistry; Cancer; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991356,0.00041123,0.0002943355,0.0001694256,0.0001000089,0.0001107031,0.000211869,0.0002180222,0.001474177],"category_scores_gemma":[0.00008099946,0.0001506902,0.0003459638,0.0001412577,0.0001381354,0.0001580423,0.00009693101,0.000495233,0.000427466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718083,"about_ca_system_score_gemma":0.0001623259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005583394,"about_ca_topic_score_gemma":0.000651815,"domain_scores_codex":[0.9998921,0.00002363433,0.000008071361,0.00002733229,0.00002311211,0.00002567656],"domain_scores_gemma":[0.9999608,0.00000780648,0.00001025348,0.000006676854,0.000006776246,0.000007707295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003412208,0.0001549002,0.0001122713,0.0001521964,0.00002018634,0.00008658229,0.00001420903,0.0002535396,0.9932733,0.0002318094,0.0002132504,0.005146634],"study_design_scores_gemma":[0.00003344517,0.001114385,0.0006008761,0.000004546876,0.00001979521,0.0001729985,0.000005418531,0.0003852592,0.993863,0.00001684588,0.003779022,0.000004408025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611033,0.0155088,0.01497796,0.0003015373,0.000220741,0.0001647009,0.001238975,0.0004697868,0.006014252],"genre_scores_gemma":[0.9758649,0.008080391,0.006968353,0.0001205701,0.0000297108,0.0001390997,0.001387847,0.00003988125,0.007369126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474177,"threshold_uncertainty_score":0.004931569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572771335022354,"score_gpt":0.2613829959072367,"score_spread":0.2456552825570131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}