{"id":"W3155078366","doi":"10.1038/s41586-021-03458-7","title":"Structural basis of long-range to short-range synaptic transition in NHEJ","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Petrel Robertson Consulting (Canada); University of Calgary","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Ku70; Ku80; DNA ligase; DNA repair protein XRCC4; DNA repair; Autophosphorylation; DNA-PKcs; DNA; Cell biology; Chemistry; Biology; Molecular biology; Protein kinase A; Biochemistry; Phosphorylation; DNA-binding protein; Nucleotide excision repair; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007692402,0.0001072891,0.0001402774,0.00004547512,0.00001523827,0.000007167474,0.0001109491,0.0007336524,0.00005826154],"category_scores_gemma":[0.00006081862,0.0001070313,0.00008653475,0.0001705649,0.0000146356,0.000003304875,0.00003943897,0.0003471896,0.000002758602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001683454,"about_ca_system_score_gemma":0.0000391602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007213329,"about_ca_topic_score_gemma":0.0003337008,"domain_scores_codex":[0.9992357,0.00004711383,0.0001370339,0.0002793095,0.0001420061,0.0001587879],"domain_scores_gemma":[0.9995649,0.000006081932,0.00001876109,0.0002656746,0.00009205155,0.00005256805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009766268,0.00003552248,0.003377341,0.00006380311,0.00004904973,0.00008978112,0.0001635761,0.00009661693,0.9918492,0.0001029205,0.0003570919,0.003717407],"study_design_scores_gemma":[0.0003806616,0.0001551172,0.0338866,0.00004620286,0.00002575059,0.00005179154,0.00009413828,0.0001143846,0.9643834,0.000093992,0.0005809647,0.0001869894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996878,0.001798089,0.0002137584,0.0004539989,0.0001799307,0.0001357647,0.00004580283,0.000009113435,0.0002855535],"genre_scores_gemma":[0.9977427,0.00003211945,0.001135684,0.0007333063,0.00008906869,0.000009792019,0.0001246646,0.00001576128,0.000116946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03050926,"threshold_uncertainty_score":0.5658599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007103845463748626,"score_gpt":0.2493315863130794,"score_spread":0.2422277408493308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}