{"id":"W3155080651","doi":"10.1093/jn/nxab211","title":"Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA","year":2021,"lang":"en","type":"article","venue":"Journal of Nutrition","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; Université de Moncton","funders":"President's Council of Cornell Women; Multiple Sclerosis Foundation","keywords":"Mitochondrial DNA; Uracil; Respiration; Mitochondrion; Biology; DNA; Cell biology; Biochemistry; Chemistry; Gene; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291945,0.0005472137,0.0003713352,0.0008003142,0.0002901174,0.0004255074,0.0003690752,0.0007811759,0.00250761],"category_scores_gemma":[0.0001870654,0.0003983129,0.0005132645,0.0004158159,0.0005430523,0.000300086,0.0002878389,0.0008083446,0.0005178366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004508499,"about_ca_system_score_gemma":0.0002881432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001648022,"about_ca_topic_score_gemma":0.002267777,"domain_scores_codex":[0.999698,0.00003798809,0.00004055471,0.00009068387,0.00007426063,0.00005858711],"domain_scores_gemma":[0.9995752,0.00005522536,0.0001742088,0.00004474816,0.00003038605,0.0001202083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002263107,0.00002273992,0.0001952016,0.00002892558,0.00001243957,0.00006989355,0.00001875551,0.00005566153,0.9988092,0.0001235276,0.0000333325,0.00040398],"study_design_scores_gemma":[0.0000293108,0.0002066914,0.00323706,0.000007346838,0.00003879652,0.0002596797,0.00004823813,0.0005808732,0.9943501,0.00009829004,0.001138004,0.000005654998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926928,0.001067137,0.003866005,0.0002076966,0.00005094363,0.00002245327,0.001075906,0.0002444676,0.0007726605],"genre_scores_gemma":[0.9915155,0.0004808516,0.001350868,0.00005936847,0.00001082168,0.00003353784,0.000854762,0.00006887867,0.00562542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250761,"threshold_uncertainty_score":0.008388758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06049328404024572,"score_gpt":0.3647631702549032,"score_spread":0.3042698862146575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}