{"id":"W3155085782","doi":"10.1021/acs.biochem.1c00145","title":"Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1","year":2021,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ubiquitin; Acetylation; Lysine; Fluorophore; Ubiquitin-conjugating enzyme; Enzyme; Biochemistry; Chemistry; Conjugate; Cell biology; Biology; Ubiquitin ligase; Fluorescence; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723177,0.0001750657,0.0001458787,0.000006401989,0.0001324303,0.00002326994,0.0004278369,0.0002203574,0.00005167854],"category_scores_gemma":[0.0002597544,0.000116123,0.0001889503,0.0001652951,0.0002070448,0.000002469468,0.0003791216,0.0001787552,0.000006744384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001689846,"about_ca_system_score_gemma":0.0002601558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001924066,"about_ca_topic_score_gemma":0.000008536223,"domain_scores_codex":[0.9989759,0.00007846111,0.0001795187,0.0003446576,0.0001768181,0.0002446694],"domain_scores_gemma":[0.9987225,0.00002630643,0.0001333394,0.0009264325,0.0001329163,0.00005852684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002551925,0.00005890667,0.0003393681,0.00006100398,0.0000555473,0.000002288365,0.00003636093,0.00001320736,0.9968015,0.00001555733,0.00178046,0.0008103025],"study_design_scores_gemma":[0.0002447724,0.00002189945,0.0008364642,0.00003172859,0.00002646856,0.00004684677,0.00007116906,0.00005074326,0.9955361,0.0000664896,0.002916741,0.0001505827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937872,0.001583825,0.00003214633,0.0007401491,0.0001168119,0.0001319854,0.00008406639,0.00001332341,0.003510496],"genre_scores_gemma":[0.995927,0.00005229037,0.00005202668,0.0002068279,0.0001957804,0.00002020985,0.00007954046,0.00002042952,0.003445879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002139819,"threshold_uncertainty_score":0.4735358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165071553566297,"score_gpt":0.2307932440601606,"score_spread":0.2191425285244977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}