{"id":"W3155290787","doi":"10.1016/j.jaci.2021.03.045","title":"Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Helmut Horten Stiftung; Deutsches Zentrum für Lungenforschung; Bundesministerium für Bildung und Forschung; National Institute of Allergy and Infectious Diseases; Universität Zürich; Deutsche Forschungsgemeinschaft; E-Rare; National Institute of Diabetes and Digestive and Kidney Diseases; Novartis Foundation","keywords":"Interferon; Biology; Immunology; Immune system; Nucleic acid; Innate immune system; Primary immunodeficiency; Inflammation; Viral replication; Virology; Virus; Transcriptome; Immunity; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058565,0.0007919446,0.0004834383,0.00118691,0.0005502895,0.0004084553,0.0003466331,0.0006275355,0.002111244],"category_scores_gemma":[0.0008864859,0.0003203414,0.0002968161,0.0005186415,0.0006319914,0.0003040808,0.0004408806,0.0004462566,0.0001485178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092516,"about_ca_system_score_gemma":0.0002173545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00283999,"about_ca_topic_score_gemma":0.001672315,"domain_scores_codex":[0.9998462,0.00004833483,0.00001831223,0.00003884872,0.00002416265,0.00002401764],"domain_scores_gemma":[0.9995657,0.0001031321,0.0001792448,0.00002562644,0.00002543905,0.0001009992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01427145,0.0005858719,0.7684923,0.0001515155,0.0003835,0.02630667,0.001226439,0.0005678188,0.173367,0.0005433194,0.0005257028,0.01357844],"study_design_scores_gemma":[0.0002103052,0.001121295,0.9578526,0.00004022973,0.0002963984,0.03064366,0.0005921689,0.001122682,0.006844079,0.0004474492,0.0008012248,0.0000278726],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992519,0.0002829195,0.0001516105,0.00003927512,0.000003585142,0.000004054139,0.00006039448,0.000006896283,0.0001992449],"genre_scores_gemma":[0.9993891,0.0001135955,0.0001230258,0.0000140838,0.000005791677,0.00000379223,0.00006213086,0.000003954714,0.0002844871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00283999,"threshold_uncertainty_score":0.007062852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170931450768812,"score_gpt":0.3272106002698642,"score_spread":0.3055012857621761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}