{"id":"W3155290787","doi":"10.1016/j.jaci.2021.03.045","title":"Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Helmut Horten Stiftung; Deutsches Zentrum für Lungenforschung; Bundesministerium für Bildung und Forschung; National Institute of Allergy and Infectious Diseases; Universität Zürich; Deutsche Forschungsgemeinschaft; E-Rare; National Institute of Diabetes and Digestive and Kidney Diseases; Novartis Foundation","keywords":"Interferon; Biology; Immunology; Immune system; Nucleic acid; Innate immune system; Primary immunodeficiency; Inflammation; Viral replication; Virology; Virus; Transcriptome; Immunity; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008597432,0.0001210567,0.0004507276,0.0001762562,0.000132978,0.00001854279,0.0001101992,0.0003487158,0.0001918935],"category_scores_gemma":[0.0009277141,0.0001041503,0.0001139138,0.0001104225,0.0002892097,0.0001239997,0.0001460675,0.000637926,0.00002707212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003652059,"about_ca_system_score_gemma":0.0001005645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006018538,"about_ca_topic_score_gemma":0.0007358483,"domain_scores_codex":[0.9975618,0.0009166839,0.001075255,0.0002013696,0.00002730569,0.0002176168],"domain_scores_gemma":[0.9988607,0.0004661334,0.0002623247,0.0001669191,0.000211605,0.00003235048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001515363,0.0008829761,0.04416429,0.00001886744,0.0008091018,0.00008057764,0.0009281864,0.00001247644,0.9103,0.005178061,0.0002419973,0.03586811],"study_design_scores_gemma":[0.006826483,0.006054644,0.8977935,0.0002190247,0.00007127307,0.002624224,0.002258891,0.000006559178,0.04352921,0.0007531465,0.03953447,0.0003285525],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922965,0.005602878,0.0001182191,0.0007429373,0.0008868839,0.0000723588,0.000001735724,0.000008731136,0.00026974],"genre_scores_gemma":[0.9975443,0.001659152,0.00006622332,0.00009527495,0.00004042514,0.000002205458,0.000004165732,0.000006315472,0.0005818878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8667708,"threshold_uncertainty_score":0.4247126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170931450768812,"score_gpt":0.3272106002698642,"score_spread":0.3055012857621761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}