{"id":"W3155322721","doi":"10.1002/cpt.2269","title":"Rational Clinical Dose Selection of Adeno‐Associated Virus‐Mediated Gene Therapy Based on Allometric Principles","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Adeno-associated virus; Genetic enhancement; In vivo; Computational biology; Gene transfer; Vector (molecular biology); Biology; Gene; Allometry; Medicine; Bioinformatics; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003802969,0.0007904235,0.0008243722,0.00124011,0.0003083513,0.001385209,0.0007502614,0.0006344435,0.001301368],"category_scores_gemma":[0.00534993,0.0003921949,0.0003713452,0.0005622234,0.001049889,0.001177687,0.0006346938,0.001539469,0.0005924665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008113285,"about_ca_system_score_gemma":0.0009190754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003335919,"about_ca_topic_score_gemma":0.0004331942,"domain_scores_codex":[0.9981543,0.0007029891,0.0001073028,0.0002456856,0.0006939249,0.00009570835],"domain_scores_gemma":[0.9986028,0.000644391,0.0004153589,0.0001449408,0.0001258467,0.00006671237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001096307,0.001224941,0.00554867,0.0004502806,0.00009344586,0.0001705655,0.0004026896,0.04627915,0.6846668,0.01490821,0.002559438,0.2425995],"study_design_scores_gemma":[0.0004469926,0.01638768,0.02007436,0.0002614854,0.0002437659,0.001717015,0.0002938166,0.1334459,0.7478594,0.01518855,0.0638475,0.0002335455],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3720315,0.01614675,0.5831762,0.001978249,0.0004125577,0.002495656,0.0004368579,0.001413288,0.02190894],"genre_scores_gemma":[0.8801324,0.0044636,0.1111401,0.0007484307,0.0001405076,0.00113008,0.0001998904,0.0002934275,0.001751637],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003802969,"threshold_uncertainty_score":0.02011228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1528450336788684,"score_gpt":0.4556251334500514,"score_spread":0.302780099771183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}