{"id":"W3155322721","doi":"10.1002/cpt.2269","title":"Rational Clinical Dose Selection of Adeno‐Associated Virus‐Mediated Gene Therapy Based on Allometric Principles","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Adeno-associated virus; Genetic enhancement; In vivo; Computational biology; Gene transfer; Vector (molecular biology); Biology; Gene; Allometry; Medicine; Bioinformatics; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002513014,0.0003277566,0.000603568,0.0001850725,0.0001504281,0.00002156104,0.0004717732,0.000823177,0.0007271877],"category_scores_gemma":[0.0004621703,0.0003134145,0.0005292606,0.0008738622,0.0005423678,0.000006875089,0.0001175451,0.0008251147,0.00005140502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006029811,"about_ca_system_score_gemma":0.001353693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002195851,"about_ca_topic_score_gemma":0.00003697355,"domain_scores_codex":[0.9940744,0.002732659,0.001334312,0.0008403879,0.0004945981,0.0005236434],"domain_scores_gemma":[0.9965714,0.001387841,0.0004792252,0.0004765405,0.000839584,0.0002454535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01117033,0.004983128,0.03403357,0.000008281218,0.001808256,0.00001860761,0.00001263831,0.001121679,0.9367508,0.000003350603,0.00342355,0.00666578],"study_design_scores_gemma":[0.01183256,0.01336042,0.05991044,0.00001095828,0.000239293,0.000005345304,0.00001020003,0.009055126,0.8549674,0.00002869022,0.05013219,0.0004474017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941658,0.001694121,0.0002950722,0.002042076,0.001034668,0.0004845172,0.0001058776,0.0000461585,0.0001316936],"genre_scores_gemma":[0.9442552,0.01229152,0.0004539789,0.04066196,0.001065542,0.00005968713,0.0007143233,0.00008209314,0.0004157029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08178345,"threshold_uncertainty_score":0.9999318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1528450336788684,"score_gpt":0.4556251334500514,"score_spread":0.302780099771183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}