{"id":"W3155385010","doi":"10.1038/s41587-021-00891-x","title":"Genome-wide specificity of prime editors in plants","year":2021,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Genetics","funders":"","keywords":"Retrotransposon; Biology; Genome; Primer (cosmetics); Genetics; RNA; Computational biology; Reverse transcriptase; Telomere; Murine leukemia virus; Virus; Gene; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007353555,0.0004306967,0.0007490545,0.0005901477,0.0006845437,0.002063187,0.0007255379,0.0008807002,0.006251814],"category_scores_gemma":[0.001240467,0.0007785956,0.0005031058,0.0002522711,0.0006411664,0.0009152422,0.0009714127,0.002202809,0.002827735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005048655,"about_ca_system_score_gemma":0.0003083019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805434,"about_ca_topic_score_gemma":0.001328957,"domain_scores_codex":[0.9988534,0.0001172617,0.00006100361,0.0006350554,0.0001884273,0.0001449472],"domain_scores_gemma":[0.9981186,0.0007045969,0.0002991807,0.0002591802,0.0002180062,0.0004004657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009456729,0.000009613584,0.0002404675,0.00004138568,0.000007049874,0.00006221483,0.00003438058,0.00007204682,0.9961531,0.0005210039,0.000201059,0.002563204],"study_design_scores_gemma":[0.00001467573,0.00005210344,0.00472436,0.000005545819,0.00002171994,0.0003939515,0.00004448711,0.001112742,0.9858704,0.0003792106,0.007363469,0.00001730328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9089085,0.005826391,0.06112279,0.001153667,0.0009445047,0.00007665901,0.00119982,0.00294119,0.01782659],"genre_scores_gemma":[0.9751007,0.0006012122,0.009675806,0.0004307459,0.0001454068,0.00002670402,0.0009267135,0.0008766435,0.01221617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006251814,"threshold_uncertainty_score":0.02091438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003386455373979908,"score_gpt":0.2504060085970241,"score_spread":0.2470195532230442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}