{"id":"W3155385010","doi":"10.1038/s41587-021-00891-x","title":"Genome-wide specificity of prime editors in plants","year":2021,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Genetics","funders":"","keywords":"Retrotransposon; Biology; Genome; Primer (cosmetics); Genetics; RNA; Computational biology; Reverse transcriptase; Telomere; Murine leukemia virus; Virus; Gene; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007128573,0.0001046536,0.000155415,0.00009286443,0.00001195175,0.000002782525,0.0001721522,0.001091797,0.0000173604],"category_scores_gemma":[0.0001676023,0.0001095118,0.00004765327,0.0001629929,0.00005790686,9.334145e-7,0.0001340876,0.0003819717,0.000003146198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121578,"about_ca_system_score_gemma":0.00004920765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003392821,"about_ca_topic_score_gemma":0.00004759919,"domain_scores_codex":[0.9992664,0.00001468709,0.0001648102,0.0002891164,0.00007345737,0.0001915563],"domain_scores_gemma":[0.9995268,0.00001101823,0.00003813253,0.0003611777,0.00003753696,0.00002534736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001684575,0.00004011567,0.003829264,0.00001213612,0.00001760179,0.00002098672,0.000007944887,0.00005384907,0.9944534,0.00007686319,0.0005678048,0.0009032103],"study_design_scores_gemma":[0.0002099337,0.00004996431,0.02309482,0.000007597776,0.000002679453,0.00001976474,0.00003617289,0.000006721392,0.8709602,0.00005120287,0.1054645,0.00009644694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901478,0.006202753,0.001728753,0.0005075096,0.0008337145,0.00007242956,0.00001969032,0.00002086812,0.0004665012],"genre_scores_gemma":[0.9975016,0.0005655881,0.001232173,0.00005879523,0.0004271186,0.000002865169,0.00006510973,0.00001234238,0.0001343845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1234932,"threshold_uncertainty_score":0.8420936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003386455373979908,"score_gpt":0.2504060085970241,"score_spread":0.2470195532230442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}