{"id":"W3155458031","doi":"10.1007/s10928-021-09752-1","title":"Use of population PK/PD approach to model the thrombin generation assay: assessment in haemophilia A plasma samples spiked by a TFPI antibody","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacokinetics and Pharmacodynamics","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Haemophilia; Coagulation; In vivo; Population; Tissue factor pathway inhibitor; Antibody; Chemistry; Ex vivo; Immunology; Chromatography; Internal medicine; Pharmacology; Medicine; In vitro; Tissue factor; Biochemistry; Biology; Surgery; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007757641,0.0002005611,0.0004566201,0.0002262714,0.00007910317,0.00006711911,0.0001123832,0.00008112554,0.00002471607],"category_scores_gemma":[0.00007723115,0.0001399176,0.000126847,0.0004092626,0.00005255879,0.0001667235,0.0000792868,0.0005202088,3.533347e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361778,"about_ca_system_score_gemma":0.0002141969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004653133,"about_ca_topic_score_gemma":0.000009695538,"domain_scores_codex":[0.9979534,0.0002167544,0.0007125167,0.0002205893,0.0006426862,0.0002540772],"domain_scores_gemma":[0.9988049,0.0001422536,0.0002639674,0.0001553493,0.0004101438,0.0002233744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002724836,0.001112222,0.01717889,0.000140337,0.0002463357,0.0000608275,0.0003679703,0.04459333,0.9282109,0.0001922928,0.002344422,0.005280056],"study_design_scores_gemma":[0.00310437,0.0002034195,0.01117036,0.00008131556,0.0003333879,0.0001942571,0.00007847253,0.9546905,0.02948933,0.00008769368,0.0004324442,0.0001344114],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882854,0.0004772526,0.007971529,0.002410835,0.000170428,0.0004623691,0.00009321157,0.000005259235,0.0001237188],"genre_scores_gemma":[0.9818261,0.003474473,0.01369999,0.0003350936,0.000177931,0.000007362495,0.0002636384,0.00002794991,0.000187502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9100972,"threshold_uncertainty_score":0.5705674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09243769130852748,"score_gpt":0.3941877556631207,"score_spread":0.3017500643545932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}