{"id":"W3155579060","doi":"10.3389/fcell.2021.671067","title":"Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Fonds de Recherche du Québec - Santé; Genome Canada; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"ISG15; SUMO protein; Ubiquitin; SUMO enzymes; Biology; Crosstalk; Cell biology; Interferon; Ubiquitin ligase; RNF4; Proteomics; Proteome; Interferon-stimulated gene; IRF3; Immunoprecipitation; NEDD8; Genetics; Gene; Zinc finger; Transcription factor; Innate immune system; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004064882,0.000848939,0.0009646161,0.001647222,0.0002445061,0.001058148,0.000815319,0.001249096,0.00324952],"category_scores_gemma":[0.0004032479,0.0002123663,0.0002803766,0.002015231,0.0005372111,0.001724073,0.0008465741,0.001636409,0.002472382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006920894,"about_ca_system_score_gemma":0.0008043239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003880448,"about_ca_topic_score_gemma":0.0005919219,"domain_scores_codex":[0.9998697,0.0000221567,0.0000153894,0.00002843742,0.00004640389,0.0000178897],"domain_scores_gemma":[0.9998177,0.00006094835,0.00002469168,0.000007721774,0.00005357719,0.0000354355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009048402,0.00005560594,0.0001571623,0.008681024,0.00004890426,0.000251403,0.00005597904,0.0003589441,0.004416257,0.007305006,0.03023613,0.9483432],"study_design_scores_gemma":[0.000009497331,0.00005719523,0.0006775653,0.001464127,0.00003237546,0.001102296,0.00004718776,0.00007219474,0.000628791,0.003809564,0.9920856,0.00001356601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001031351,0.9981687,0.000140975,0.0003119647,0.0002741527,0.00000168284,0.0000104317,0.000007322433,0.0009816887],"genre_scores_gemma":[0.0008882966,0.9975243,0.0001703643,0.0002012402,0.0003573816,0.000004023647,0.00002571471,0.000001779612,0.0008269095],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00324952,"threshold_uncertainty_score":0.01087075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02689259949377052,"score_gpt":0.2935474856498558,"score_spread":0.2666548861560852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}