{"id":"W3155588809","doi":"10.1002/smll.202008198","title":"Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release","year":2021,"lang":"en","type":"article","venue":"Small","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; BC Innovation Council; University of British Columbia","funders":"National Science Foundation","keywords":"Chemistry; Drug; Liposome; In vivo; Biophysics; Drug delivery; Extravasation; Doxorubicin; Azobenzene; Nile red; Nanoparticle; Cytotoxicity; In vitro; Pharmacology; Nanotechnology; Biochemistry; Molecule; Materials science; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000295082,0.0001986451,0.0003273084,0.00002534388,0.0001794367,0.0001436968,0.0003352513,0.00009249135,0.00363481],"category_scores_gemma":[0.0002684306,0.0001841718,0.0001013614,0.0002268113,0.00007553405,0.0002110963,0.0001592943,0.0001449175,0.0003452319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000872434,"about_ca_system_score_gemma":0.0002889752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009784048,"about_ca_topic_score_gemma":0.000008243345,"domain_scores_codex":[0.9982989,0.00008454506,0.0003293021,0.0005355304,0.0002118715,0.0005397852],"domain_scores_gemma":[0.9988264,0.00007878625,0.0001127224,0.0006348044,0.0001200084,0.0002272829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001683086,0.0001498805,0.00002549797,0.00004874135,0.000009346988,0.00009700564,0.0001992945,0.00003592136,0.985454,0.00002416775,0.01371801,0.00006986057],"study_design_scores_gemma":[0.001276848,0.00001069626,0.00001901743,0.00006767151,0.00002295364,0.00003133257,0.000246877,0.0002398299,0.986432,0.0002651149,0.01114108,0.00024657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870044,0.0003287062,0.00006099433,0.0007948827,0.0003889453,0.0001904006,0.00003127508,0.000179357,0.01102102],"genre_scores_gemma":[0.9740447,0.00007356217,0.01048055,0.000357515,0.0002827116,0.00009267109,0.00003517009,0.00003766515,0.01459548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01295973,"threshold_uncertainty_score":0.997276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382933636187501,"score_gpt":0.2122891135878867,"score_spread":0.1984597772260117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}