{"id":"W3155589570","doi":"10.1002/stem.3385","title":"Cell-Intrinsic WNT4 Promotes Hematopoietic Stem and Progenitor Cell Self-Renewal","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Biology; WNT4; Stem cell; Cell biology; Haematopoiesis; Wnt signaling pathway; Progenitor cell; Stromal cell; Hematopoietic stem cell; Stem cell factor; Adult stem cell; Bone marrow; Immunology; Cancer research; Cellular differentiation; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095252,0.0002482748,0.0001738423,0.0003058649,0.000105579,0.0002542727,0.000121974,0.0001521102,0.001873362],"category_scores_gemma":[0.0001077189,0.0001007027,0.0001806104,0.0001522908,0.0002052588,0.0001525164,0.0002783431,0.0003419451,0.0004614748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768148,"about_ca_system_score_gemma":0.0003118368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007855663,"about_ca_topic_score_gemma":0.001189822,"domain_scores_codex":[0.999889,0.0000158711,0.0000128746,0.00001861731,0.00003836002,0.00002524727],"domain_scores_gemma":[0.9999098,0.00001080726,0.00002462852,0.00001039361,0.00001508086,0.00002926043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005434814,0.000008329566,0.0002659125,0.00003516967,0.0000024575,0.00002931172,0.000007272179,0.00002436122,0.9984741,0.00009637541,0.00002675618,0.0009755048],"study_design_scores_gemma":[0.000007823945,0.0000852143,0.00477215,0.000008054647,0.00001049039,0.0001100715,0.00002733743,0.0004143313,0.9919456,0.00005515403,0.002561951,0.000001778256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915273,0.001854553,0.00364748,0.00008201928,0.00002060849,0.00002800363,0.0005964416,0.0001155718,0.002128032],"genre_scores_gemma":[0.9908791,0.0011328,0.002151714,0.00003073463,0.000007220745,0.00002560328,0.0006228844,0.00002732508,0.005122656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873362,"threshold_uncertainty_score":0.006267071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02570060758888778,"score_gpt":0.2944851730423695,"score_spread":0.2687845654534817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}