{"id":"W3155610870","doi":"10.1002/slct.202100671","title":"Palladium‐Catalyzed Regioselective Coupling of Amidines and 1,2,3‐Triiodobenzenes: Facile Synthesis of 2,3‐Diiodinated <i>N</i> ‐Arylbenzimidamides as Potential MDM <sub>2</sub> and MDM <sub>4</sub> Inhibitors","year":2021,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Jordan University of Science and Technology","keywords":"Regioselectivity; Amination; Chemistry; Palladium; Steric effects; Amidine; Catalysis; Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498994,0.0004783887,0.0001825498,0.0001417585,0.0001192408,0.0001966396,0.0003935467,0.0002331705,0.0006728836],"category_scores_gemma":[0.0001320945,0.0001524321,0.0001743898,0.000144954,0.0001813384,0.0002000966,0.0002309678,0.0003138785,0.0003169336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002839871,"about_ca_system_score_gemma":0.0001957768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003896009,"about_ca_topic_score_gemma":0.0008917357,"domain_scores_codex":[0.9998916,0.00002292056,0.000009104275,0.00002493483,0.00001952136,0.00003189749],"domain_scores_gemma":[0.999962,0.000006066165,0.00001359855,0.000004362732,0.000004964984,0.000009028548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004821759,0.00002004159,0.00009795311,0.00007916961,0.00001147151,0.0001368345,0.00002799093,0.0001832373,0.9945288,0.0004588812,0.00009084696,0.004316454],"study_design_scores_gemma":[0.000009109142,0.0001121361,0.0003037862,0.000002147025,0.00000778875,0.0001996897,0.000007310715,0.0002204438,0.9961248,0.00004069137,0.002967998,0.00000404567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9152029,0.009287905,0.05551028,0.0001904215,0.0001010807,0.0001891154,0.0006219255,0.0004091184,0.01848735],"genre_scores_gemma":[0.9872423,0.002224797,0.008252478,0.00004257697,0.00001490464,0.0000410588,0.0002078649,0.00002093789,0.001952956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006728836,"threshold_uncertainty_score":0.002250969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00966016026588406,"score_gpt":0.2267962705369976,"score_spread":0.2171361102711135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}