{"id":"W3155610870","doi":"10.1002/slct.202100671","title":"Palladium‐Catalyzed Regioselective Coupling of Amidines and 1,2,3‐Triiodobenzenes: Facile Synthesis of 2,3‐Diiodinated <i>N</i> ‐Arylbenzimidamides as Potential MDM <sub>2</sub> and MDM <sub>4</sub> Inhibitors","year":2021,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Jordan University of Science and Technology","keywords":"Regioselectivity; Amination; Chemistry; Palladium; Steric effects; Amidine; Catalysis; Combinatorial chemistry; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004935222,0.0006637511,0.001095024,0.0001677568,0.0002424127,0.0001002411,0.0002812562,0.0005528278,0.0001366362],"category_scores_gemma":[0.00361585,0.000756662,0.0002939571,0.001054392,0.0005048614,0.0002230887,0.0002766607,0.0004146191,0.00000454133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059998,"about_ca_system_score_gemma":0.0005771122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006678992,"about_ca_topic_score_gemma":0.00001680834,"domain_scores_codex":[0.996322,0.00005269058,0.001127167,0.00118633,0.0007110231,0.0006008123],"domain_scores_gemma":[0.9961047,0.000984192,0.0007913784,0.00069428,0.001119419,0.000306096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002958183,0.0002030437,0.001611659,0.001820873,0.0004242195,0.00004208708,0.0001575822,0.0002602706,0.9898886,0.00002391176,0.000376756,0.004895181],"study_design_scores_gemma":[0.001217223,0.00002903953,0.0003404709,0.0005217695,0.0004505414,0.0003630526,0.0005688714,0.001439356,0.994087,0.0002428236,0.00007292783,0.0006669087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955249,0.002617894,0.0003850232,0.00008393835,0.000108131,0.000174272,0.0002270852,0.0001581217,0.0007206561],"genre_scores_gemma":[0.9973696,0.00139627,0.0002747698,0.00002374292,0.0002385694,0.00006653485,0.00043794,0.0001065987,0.0000860136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004228272,"threshold_uncertainty_score":0.9994884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00966016026588406,"score_gpt":0.2267962705369976,"score_spread":0.2171361102711135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}