{"id":"W3155626750","doi":"10.18632/aging.202950","title":"Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Universitätsklinikum Hamburg-Eppendorf; European Regional Development Fund; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; Cambridge Institute for Medical Research, University of Cambridge; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Arizona Biomedical Research Commission; National Institute of Diabetes and Digestive and Kidney Diseases; IXICO; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Université Pierre et Marie Curie; University of Bristol; H. Lundbeck A/S; Meso Scale Diagnostics; Agence Française de Sécurité Sanitaire des Produits de Santé; Sanofi; Fondation de France; Fonds Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; Belgian Federal Science Policy Office; University College London; Albert-Ludwigs-Universität Freiburg; Institut National de la Santé et de la Recherche Médicale; Medical Research Council; Servier; Universität Heidelberg; Genentech; Fondation pour la Recherche sur Alzheimer; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Instituto de Investigación Marqués de Valdecilla; Vlaamse regering; University of Oxford; Eisai; University of Southern California; Wellcome Trust; Eli Lilly and Company; Brigham Young University; Canadian Institutes of Health Research; University of Southampton; Universiteit Antwerpen; Northern California Institute for Research and Education; Institute of Genetics; Agence Nationale de la Recherche; Biogen; BioClinica; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Arizona Department of Health Services; F. Hoffmann-La Roche; Emory University; Cardiff University; U.S. Department of Defense; Mutuelle Générale de l'Education Nationale; Bristol-Myers Squibb; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Rheinische Friedrich-Wilhelms-Universität Bonn","keywords":"Apolipoprotein E; Disease; Concordance; Allele; Genome-wide association study; Dementia; Alzheimer's disease; Biology; Omics; Computational biology; Biomarker; Bioinformatics; Medicine; Genetics; Gene; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002541822,0.001134273,0.001296196,0.003200738,0.0005388288,0.001975782,0.0006460481,0.0005670683,0.002991277],"category_scores_gemma":[0.003027959,0.0002737193,0.001808722,0.001816986,0.0003398125,0.0008769734,0.001514287,0.0007817168,0.0005507132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004786195,"about_ca_system_score_gemma":0.0008650548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867004,"about_ca_topic_score_gemma":0.003864676,"domain_scores_codex":[0.9991038,0.0002417161,0.00005369648,0.0003660536,0.0001163976,0.0001182956],"domain_scores_gemma":[0.9984543,0.0005153202,0.000376501,0.000271231,0.0002365775,0.0001460368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001963771,0.0004645786,0.604114,0.001106365,0.009232767,0.001312067,0.0007689325,0.00378811,0.221331,0.004689933,0.004824001,0.1464044],"study_design_scores_gemma":[0.0000603164,0.0004198623,0.9400418,0.0002434778,0.003920319,0.001555011,0.0005509457,0.01159532,0.01482675,0.01597355,0.01071618,0.00009635518],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8704402,0.01316797,0.08921972,0.002466352,0.0002765292,0.0001722991,0.0144518,0.000814702,0.008990473],"genre_scores_gemma":[0.9584392,0.001944381,0.03038537,0.0007548933,0.0001407803,0.0001062369,0.006928355,0.0001871419,0.001113638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003200738,"threshold_uncertainty_score":0.01344264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03667237207692829,"score_gpt":0.3225361943539171,"score_spread":0.2858638222769888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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