{"id":"W3155626750","doi":"10.18632/aging.202950","title":"Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Universitätsklinikum Hamburg-Eppendorf; European Regional Development Fund; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; Cambridge Institute for Medical Research, University of Cambridge; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Arizona Biomedical Research Commission; National Institute of Diabetes and Digestive and Kidney Diseases; IXICO; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Université Pierre et Marie Curie; University of Bristol; H. Lundbeck A/S; Meso Scale Diagnostics; Agence Française de Sécurité Sanitaire des Produits de Santé; Sanofi; Fondation de France; Fonds Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; Belgian Federal Science Policy Office; University College London; Albert-Ludwigs-Universität Freiburg; Institut National de la Santé et de la Recherche Médicale; Medical Research Council; Servier; Universität Heidelberg; Genentech; Fondation pour la Recherche sur Alzheimer; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Instituto de Investigación Marqués de Valdecilla; Vlaamse regering; University of Oxford; Eisai; University of Southern California; Wellcome Trust; Eli Lilly and Company; Brigham Young University; Canadian Institutes of Health Research; University of Southampton; Universiteit Antwerpen; Northern California Institute for Research and Education; Institute of Genetics; Agence Nationale de la Recherche; Biogen; BioClinica; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Arizona Department of Health Services; F. Hoffmann-La Roche; Emory University; Cardiff University; U.S. Department of Defense; Mutuelle Générale de l'Education Nationale; Bristol-Myers Squibb; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Rheinische Friedrich-Wilhelms-Universität Bonn","keywords":"Apolipoprotein E; Disease; Concordance; Allele; Genome-wide association study; Dementia; Alzheimer's disease; Biology; Omics; Computational biology; Biomarker; Bioinformatics; Medicine; Genetics; Gene; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201825,0.0002754641,0.0004799358,0.0004732643,0.0002334046,0.0001220062,0.0001205497,0.00006131448,0.0003359872],"category_scores_gemma":[0.0002639122,0.0002448027,0.0004883237,0.001915751,0.00007453062,0.0001348067,0.0001288892,0.000135277,0.0001488251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001354824,"about_ca_system_score_gemma":0.0002841224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001361431,"about_ca_topic_score_gemma":0.0001725008,"domain_scores_codex":[0.9977312,0.0002033355,0.0003253108,0.0006505828,0.0005797701,0.0005097722],"domain_scores_gemma":[0.9978647,0.0001373278,0.00008862029,0.0005316896,0.0004917965,0.0008858732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007385665,0.002907675,0.7135864,0.00004518603,0.2579776,0.008115378,0.001352617,0.0001233835,0.00580068,0.00007731465,0.002713105,0.006562119],"study_design_scores_gemma":[0.003394641,0.0001070165,0.9296514,0.000224021,0.03997501,0.00001579449,0.002237216,0.00152387,0.02183166,0.00009882999,0.0004010843,0.000539399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652247,0.03136487,0.0004168714,0.001566155,0.00008935765,0.0004926312,0.0002740906,0.000133896,0.0004373824],"genre_scores_gemma":[0.9964064,0.0008420433,0.0007327052,0.0002610476,0.00006444918,0.00008956909,0.001358988,0.0000393166,0.000205512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2180026,"threshold_uncertainty_score":0.9982764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03667237207692829,"score_gpt":0.3225361943539171,"score_spread":0.2858638222769888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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