{"id":"W3155638202","doi":"10.1093/jb/mvab031","title":"Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue","year":2021,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Translocator protein; Photoaffinity labeling; Cholesterol; Chemistry; Radioligand; Biochemistry; Mitochondrion; Fluorescence; Binding protein; Binding site; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004446323,0.0001565591,0.0002290382,0.00003600625,0.0001204091,0.00004287556,0.000384338,0.0001162786,0.00001937626],"category_scores_gemma":[0.0001073989,0.00009865307,0.0001394867,0.0001872039,0.0001564407,0.000006759419,0.0001263296,0.0002226762,0.000001439581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001924347,"about_ca_system_score_gemma":0.0001861918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001326449,"about_ca_topic_score_gemma":0.000008822845,"domain_scores_codex":[0.9987471,0.0001500277,0.0003841373,0.0001906035,0.0002977705,0.0002304205],"domain_scores_gemma":[0.9990166,0.00003517727,0.0002142727,0.0004125214,0.0001904339,0.0001310363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002737931,0.00005438807,0.0001701507,0.0000467084,0.00009589516,0.00001015819,0.0001187161,0.00003841101,0.9980508,3.022665e-7,0.0003046881,0.0008359927],"study_design_scores_gemma":[0.0006193238,0.0001458541,0.0002522976,0.0001541367,0.0000430271,0.0001792849,0.0004353069,0.000009324853,0.9945261,0.000002229242,0.003526122,0.000107009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966978,0.001731535,0.0006589399,0.0005242577,0.00007575698,0.0002073414,0.00004336559,0.000001813526,0.00005918404],"genre_scores_gemma":[0.9983757,0.0002457584,0.0004073737,0.00008841097,0.0006579165,0.00000481113,0.000009763364,0.00002040467,0.0001899342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003524713,"threshold_uncertainty_score":0.4022956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104625873778932,"score_gpt":0.2821655854027381,"score_spread":0.2611193266649488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}