{"id":"W3155638202","doi":"10.1093/jb/mvab031","title":"Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue","year":2021,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Translocator protein; Photoaffinity labeling; Cholesterol; Chemistry; Radioligand; Biochemistry; Mitochondrion; Fluorescence; Binding protein; Binding site; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011409,0.0002764084,0.0002557863,0.0001460746,0.0002177729,0.0002548402,0.0002956799,0.0003227948,0.0008621768],"category_scores_gemma":[0.000202372,0.0001393416,0.0002449214,0.0001565719,0.0003365444,0.0001713798,0.0002942104,0.0004667466,0.0003108182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000392299,"about_ca_system_score_gemma":0.0002182714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133593,"about_ca_topic_score_gemma":0.001955413,"domain_scores_codex":[0.999808,0.00002613229,0.000008149985,0.00006480744,0.00004827318,0.00004475223],"domain_scores_gemma":[0.9998816,0.00004639179,0.00002325937,0.00001360963,0.00001303354,0.00002214802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002055265,0.000003874149,0.00003065822,0.00001714561,0.000002028973,0.00001869605,0.000009563943,0.00001146511,0.9996234,0.00003209831,0.000008971377,0.0002214849],"study_design_scores_gemma":[0.000003484059,0.00007640503,0.000945411,0.000002147754,0.00000566742,0.00009981845,0.00001245591,0.0002407333,0.9977326,0.00001135532,0.0008670645,0.000002869349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911374,0.001298257,0.006240541,0.00009484503,0.00002307503,0.00002660313,0.00007981156,0.00004428507,0.001055218],"genre_scores_gemma":[0.9903232,0.000968302,0.004942149,0.00006726465,0.00001426939,0.00003042297,0.0002443205,0.00002131873,0.003388782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133593,"threshold_uncertainty_score":0.002884269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104625873778932,"score_gpt":0.2821655854027381,"score_spread":0.2611193266649488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}