{"id":"W3155677758","doi":"10.3389/fimmu.2021.667989","title":"Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Innovative Medicines Initiative; Diabetes Canada; European Federation of Pharmaceutical Industries and Associations; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Autoimmunity; Immunology; Pathogenesis; Immune system; Biology; Antigen; Mechanism (biology); Autoantibody; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040454,0.0001320471,0.0002302927,0.00008554217,0.0000323706,0.00001325146,0.0001169864,0.0003027885,0.00001852324],"category_scores_gemma":[0.0001228395,0.000125847,0.00003932333,0.0001976691,0.0001755652,0.000003376662,0.0001081598,0.0001416753,0.000002691672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002160812,"about_ca_system_score_gemma":0.00005773478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008821561,"about_ca_topic_score_gemma":0.00004928245,"domain_scores_codex":[0.9989285,0.0001910202,0.0001824643,0.0003346161,0.00003873902,0.0003246465],"domain_scores_gemma":[0.9997118,0.00001713946,0.00004246275,0.000170741,0.00003191269,0.00002598322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002282541,0.0003058125,0.6632379,0.00001980552,0.0005494081,0.00003868994,0.000261922,0.00003346533,0.2607808,0.0002583769,0.007448934,0.06683668],"study_design_scores_gemma":[0.004891697,0.001273754,0.543218,0.00007238868,0.00004864354,0.000008835306,0.004275853,0.0004419591,0.05201656,0.0095869,0.3831198,0.001045622],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8495333,0.148861,0.00005588217,0.0002751357,0.0006932867,0.00007426063,0.000002992498,0.000007345563,0.0004968661],"genre_scores_gemma":[0.9883534,0.009951975,0.0007562913,0.0006327558,0.00002421331,0.00001628013,0.0001209339,0.00001371989,0.0001304058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3756709,"threshold_uncertainty_score":0.5131892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005552515445729688,"score_gpt":0.2091218470540512,"score_spread":0.2035693316083216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}