{"id":"W3155686188","doi":"10.1016/s2666-5247(20)30240-8","title":"A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study","year":2021,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Medical Research Council; National Institutes of Health","keywords":"Pharyngitis; Streptococcus pyogenes; Observational study; Medicine; Streptococcaceae; Microbiology; Internal medicine; Biology; Antibiotics; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134031,0.0001801866,0.0006220523,0.00007628301,0.0002540521,0.00003843299,0.00008169912,0.00005545488,0.0002224825],"category_scores_gemma":[0.00005107862,0.0001263736,0.0001767848,0.0002647477,0.00005404934,0.000112525,0.0000656684,0.0001220717,0.00001194366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006672128,"about_ca_system_score_gemma":0.0001073423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003403749,"about_ca_topic_score_gemma":0.0002965067,"domain_scores_codex":[0.9988208,0.0001264191,0.0003780216,0.0002850116,0.0001657574,0.0002240253],"domain_scores_gemma":[0.9989418,0.00007628859,0.0001672894,0.0005365176,0.0002162386,0.00006187738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002184177,0.001814539,0.6882821,0.00003207522,0.0005865394,0.00001928823,0.0003668034,0.0006002256,0.3066087,0.0005347555,0.0002797526,0.000656791],"study_design_scores_gemma":[0.02887836,0.0009640482,0.9113676,0.0001350276,0.0009469557,0.00006313236,0.0002893861,0.00317521,0.05271278,0.0009008611,0.0003253685,0.0002412739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964997,0.0001223837,0.0001818485,0.0002340143,0.00009257169,0.001402139,0.00005299434,0.00008537681,0.001328991],"genre_scores_gemma":[0.997897,0.00004649446,0.0002980458,0.0002290407,0.0002538033,0.0002636163,0.0001381244,0.00002444819,0.0008493969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2538959,"threshold_uncertainty_score":0.5153365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2614306681957002,"score_gpt":0.411904145314746,"score_spread":0.1504734771190458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}