{"id":"W3155770573","doi":"10.2337/dc20-2995","title":"Dasiglucagon—A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia: Results of Phase 3 Randomized Double-Blind Clinical Trial","year":2021,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Management and Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"","keywords":"Medicine; Hypoglycemia; Glucagon; Tolerability; Placebo; Diabetes mellitus; Adverse effect; Randomization; Dosing; Type 2 diabetes; Nausea; Anesthesia; Clinical endpoint; Insulin; Type 1 diabetes; Randomized controlled trial; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009511713,0.0002191749,0.001403679,0.0001810276,0.00006422685,0.00003432535,0.00006665209,0.0002023053,0.00002609783],"category_scores_gemma":[0.001017726,0.0001621961,0.0005616888,0.0002586364,0.0002356258,0.00009623228,0.00005251954,0.0001114436,0.000002560663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006376211,"about_ca_system_score_gemma":0.0001705787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005593977,"about_ca_topic_score_gemma":0.000008051577,"domain_scores_codex":[0.9976488,0.0003904389,0.0008727024,0.0004850901,0.0003041565,0.00029882],"domain_scores_gemma":[0.9968867,0.001649074,0.0002939064,0.0003896378,0.0006325528,0.0001480905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7678679,0.001394966,0.001439232,0.0005851025,0.001225701,0.000008132611,0.0005052412,0.000005953621,0.008517551,0.0000427089,0.0004533253,0.2179541],"study_design_scores_gemma":[0.87401,0.009277521,0.0001931867,0.0001210829,0.001313558,2.6389e-7,0.0004065364,0.0008639763,0.1120299,0.00003033284,0.001622223,0.0001313956],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883719,0.00359454,0.00001873255,0.0002392606,0.0004310217,0.006056172,0.0002329238,0.00001870566,0.001036762],"genre_scores_gemma":[0.9948128,0.0006477829,0.0004662853,0.00004300525,0.0006513865,0.0005907094,0.002352436,0.00002557891,0.0004099972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2178227,"threshold_uncertainty_score":0.6614163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294216310525196,"score_gpt":0.4075278613843857,"score_spread":0.278106230331866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}