{"id":"W3155770573","doi":"10.2337/dc20-2995","title":"Dasiglucagon—A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia: Results of Phase 3 Randomized Double-Blind Clinical Trial","year":2021,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Management and Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"","keywords":"Medicine; Hypoglycemia; Glucagon; Tolerability; Placebo; Diabetes mellitus; Adverse effect; Randomization; Dosing; Type 2 diabetes; Nausea; Anesthesia; Clinical endpoint; Insulin; Type 1 diabetes; Randomized controlled trial; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005277588,0.001326883,0.002942157,0.0003128126,0.0004191184,0.001014734,0.0006314089,0.001651948,0.004951293],"category_scores_gemma":[0.003238802,0.0004618374,0.002232706,0.0003908787,0.000956947,0.001010204,0.0003086548,0.001942401,0.0007671619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005305927,"about_ca_system_score_gemma":0.001370874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000425461,"about_ca_topic_score_gemma":0.0007412056,"domain_scores_codex":[0.9983828,0.001038066,0.0001118438,0.0001906909,0.0001286161,0.0001479073],"domain_scores_gemma":[0.9981478,0.0006970756,0.0004500632,0.0001475206,0.0001576986,0.0003999366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9790434,0.004608407,0.0003661644,0.0004409875,0.0006173388,0.00002373093,0.00003415722,0.0002441403,0.002478571,0.00005394531,0.0004644385,0.01162479],"study_design_scores_gemma":[0.9290419,0.06834213,0.001160742,0.00003417969,0.0002619961,0.00002451749,0.00001081121,0.0002289687,0.0004317428,0.00006325094,0.0003904027,0.000009406372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726448,0.009926432,0.002294342,0.0008903958,0.0006022197,0.00910261,0.00201774,0.0002418267,0.002279664],"genre_scores_gemma":[0.9743765,0.005727703,0.004311161,0.001565953,0.000701636,0.009245371,0.002036864,0.00006435549,0.001970436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005277588,"threshold_uncertainty_score":0.02791089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294216310525196,"score_gpt":0.4075278613843857,"score_spread":0.278106230331866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}