{"id":"W3155807510","doi":"10.1097/sla.0000000000004893","title":"Neoadjuvant Cytoreductive Treatment With BRAF/MEK Inhibition of Prior Unresectable Regionally Advanced Melanoma to Allow Complete Surgical Resection, REDUCTOR","year":2021,"lang":"en","type":"article","venue":"Annals of Surgery","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Seagen (Canada)","funders":"","keywords":"Medicine; Trametinib; Dabrafenib; Melanoma; Interquartile range; Clinical endpoint; Stage (stratigraphy); Surgery; Neoadjuvant therapy; MEK inhibitor; Cancer; Oncology; Internal medicine; Vemurafenib; Randomized controlled trial; Metastatic melanoma; MAPK/ERK pathway; Cancer research; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008078296,0.0004425288,0.0005769117,0.000196995,0.0001435262,0.0003099254,0.000199437,0.0002978216,0.001774319],"category_scores_gemma":[0.000525363,0.0001393666,0.0006583341,0.000100737,0.0002809613,0.0002312369,0.0001928508,0.0007419852,0.0002129807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002926256,"about_ca_system_score_gemma":0.0004920878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443314,"about_ca_topic_score_gemma":0.0005428233,"domain_scores_codex":[0.9997453,0.0001027378,0.00003065553,0.00006289747,0.00003130574,0.00002705645],"domain_scores_gemma":[0.9996743,0.00009175398,0.00009230814,0.00002693742,0.00001633264,0.0000983456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5231736,0.03617288,0.03353539,0.00272617,0.00189532,0.0002961428,0.0001901856,0.003970249,0.1191714,0.0004124346,0.002700714,0.2757556],"study_design_scores_gemma":[0.06257801,0.8420179,0.05539776,0.0002190306,0.0008570956,0.0009267165,0.00007082309,0.002407099,0.02943709,0.0001415292,0.005918572,0.0000284602],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929005,0.004618382,0.0005540969,0.0001049088,0.0001054078,0.0005249899,0.0001687357,0.00002193637,0.001001003],"genre_scores_gemma":[0.9967917,0.001249939,0.0005791281,0.0001004374,0.00008609785,0.0003245434,0.0002856674,0.000003760305,0.0005786936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774319,"threshold_uncertainty_score":0.005935669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208352866092536,"score_gpt":0.3215857646128292,"score_spread":0.2007504780035756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}