{"id":"W3155816625","doi":"10.1007/s00395-021-00865-9","title":"SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation","year":2021,"lang":"en","type":"article","venue":"Basic Research in Cardiology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Hippo signaling pathway; Myofibroblast; Cell biology; Fibroblast; CTGF; Biology; Signal transduction; Cardiac fibrosis; Actin cytoskeleton; Activator (genetics); Cell culture; Cell; Cytoskeleton; Fibrosis; Growth factor; Medicine; Pathology; Gene; Biochemistry; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359381,0.000408168,0.0002486856,0.0002811926,0.0001687312,0.00024043,0.0001675442,0.0001403904,0.001600771],"category_scores_gemma":[0.00007713566,0.0001359611,0.0003502727,0.0001820351,0.0001993456,0.0001517641,0.0002350078,0.0004908057,0.0004950039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003593102,"about_ca_system_score_gemma":0.0003820349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005749607,"about_ca_topic_score_gemma":0.001543726,"domain_scores_codex":[0.9999034,0.00001192694,0.00001198554,0.0000164313,0.00002599935,0.00003020801],"domain_scores_gemma":[0.9999629,0.000004834745,0.00001179541,0.000004546295,0.000004614697,0.00001127758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002174481,0.00006265037,0.0003288793,0.0001550774,0.00001545267,0.00005008212,0.00002105643,0.0001458857,0.9960334,0.0001639055,0.000221178,0.002585099],"study_design_scores_gemma":[0.00002936715,0.0002183871,0.002349424,0.000006678861,0.00001805144,0.0001436179,0.00001851907,0.0009045949,0.9925417,0.00003477091,0.003731342,0.000003577157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807721,0.005992318,0.006168712,0.0003284048,0.00008257975,0.0000828651,0.001538426,0.0002321922,0.004802336],"genre_scores_gemma":[0.9873746,0.00275667,0.003025848,0.00008564267,0.00001376374,0.00009363486,0.001772664,0.00002363911,0.00485352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600771,"threshold_uncertainty_score":0.00535512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005677071326119,"score_gpt":0.3351997011758175,"score_spread":0.2851429304625563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}