{"id":"W3155898306","doi":"10.1101/2021.04.13.21255409","title":"Efficacy of a nasal spray containing Iota-Carrageenan in the prophylaxis of COVID-19 in hospital personnel dedicated to patients care with COVID-19 disease A pragmatic multicenter, randomized, double-blind, placebo-controlled trial (CARR-COV-02)","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Infection Control and Ventilation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Placebo; Medicine; Odds ratio; Nasal spray; Confidence interval; Incidence (geometry); Adverse effect; Randomized controlled trial; Clinical trial; Internal medicine; Clinical endpoint; Placebo-controlled study; Double blind; Nasal administration; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003036389,0.0006163645,0.002844419,0.0009365944,0.0001161704,0.00007054058,0.0003841431,0.0003625512,0.00005053754],"category_scores_gemma":[0.01403494,0.0004023648,0.0008239626,0.0007142706,0.0002411264,0.00007762472,0.0001874332,0.0009870613,0.000002230494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006898311,"about_ca_system_score_gemma":0.003147779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002392853,"about_ca_topic_score_gemma":0.001352829,"domain_scores_codex":[0.9932564,0.002126858,0.00199057,0.0009128247,0.001236648,0.0004767131],"domain_scores_gemma":[0.9943852,0.002099992,0.001464144,0.0008303311,0.0006596026,0.0005607344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8362748,0.002571817,0.1099619,0.002559509,0.0005739245,0.0001728142,0.04473924,0.002978533,0.00007926679,0.000008674649,0.000004844943,0.00007473116],"study_design_scores_gemma":[0.9771915,0.002109769,0.008779437,0.001363932,0.001249732,0.000002901509,0.005705217,0.003144105,0.00005827998,0.000004042321,0.00001990113,0.000371188],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579507,0.0003170248,0.002424772,0.00101727,0.0006569957,0.0374661,0.00006683039,0.00004901748,0.00005129134],"genre_scores_gemma":[0.9927617,0.00001533526,0.0001620248,0.0005401475,0.0002035625,0.005715378,0.0005307996,0.00006017942,0.0000109294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1409167,"threshold_uncertainty_score":0.9998428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233847919990178,"score_gpt":0.3134119396548272,"score_spread":0.2910734604549254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}