{"id":"W3155904022","doi":"10.1101/2021.04.15.439995","title":"FAN1 nuclease processes and pauses on disease-associated slipped-DNA repeats: Mechanism against repeat expansions","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval; Hospital for Sick Children","funders":"","keywords":"Nuclease; DNA; Biology; Molecular biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289129,0.0002706822,0.000155952,0.0001427751,0.0001278401,0.0002822466,0.0002008722,0.0002469879,0.001459704],"category_scores_gemma":[0.0002194161,0.0001314668,0.0001915284,0.00005060281,0.0002454275,0.0002699415,0.0001754203,0.0003349568,0.0003235062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002616023,"about_ca_system_score_gemma":0.0001263652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142958,"about_ca_topic_score_gemma":0.0002638791,"domain_scores_codex":[0.9999043,0.00001108411,0.000004867622,0.00003413715,0.00002156836,0.00002399419],"domain_scores_gemma":[0.9998153,0.00003549955,0.0000553537,0.00003068622,0.00001936862,0.000043856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007477159,0.00000710581,0.0004558739,0.00002657283,0.000004932041,0.00005584954,0.00003720868,0.00009946814,0.9974088,0.0002684887,0.00003093003,0.001530004],"study_design_scores_gemma":[0.00001156208,0.0001767684,0.006174347,0.00001037293,0.000008873961,0.0004479382,0.00003713378,0.001163611,0.9900597,0.0001562212,0.001747466,0.000006001817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952192,0.0008904354,0.003049545,0.00003171079,0.00001216438,0.000007939024,0.00004712555,0.00009629669,0.0006455575],"genre_scores_gemma":[0.9982318,0.000113356,0.000756019,0.00001294594,0.000003473431,0.000005707691,0.00008644908,0.00001396549,0.000776219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459704,"threshold_uncertainty_score":0.00488323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02360904671968531,"score_gpt":0.2307649324594305,"score_spread":0.2071558857397452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}