{"id":"W3155916241","doi":"10.2139/ssrn.3523269","title":"Senescence Induced by BMI1 Inhibition is a Therapeutic Vulnerability in H3K27M-Mutant DIPG","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"BMI1; Senescence; Cancer research; Biology; Epigenetics; Epigenomics; Chromatin immunoprecipitation; Phenotype; In vivo; Chromatin; RNA interference; Cell biology; Stem cell; Gene; Genetics; Gene expression; RNA; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008981593,0.0002360291,0.0002974161,0.0001758735,0.0001432145,0.0001697806,0.0002140097,0.000325822,0.003216422],"category_scores_gemma":[0.0001176491,0.00008604339,0.0002760807,0.0001319982,0.0002130701,0.0001672292,0.0002028732,0.0008079573,0.0005825409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729219,"about_ca_system_score_gemma":0.0001480272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003818179,"about_ca_topic_score_gemma":0.0004221293,"domain_scores_codex":[0.9999175,0.000008046995,0.000006328471,0.00002120546,0.00001772526,0.00002915481],"domain_scores_gemma":[0.9999266,0.000007888587,0.00001527607,0.00001133776,0.000006434579,0.00003255503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007792179,0.00008554453,0.0002629221,0.00003676709,0.00001020955,0.0001811017,0.00001075724,0.00003938902,0.994422,0.0001418176,0.0001636672,0.003866629],"study_design_scores_gemma":[0.0001718619,0.005258467,0.01816282,0.00001824988,0.00009622445,0.003526644,0.00008322491,0.001411661,0.9625733,0.0004203509,0.008256474,0.00002072195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952459,0.0009485671,0.001058187,0.0001594918,0.0000786118,0.00002533252,0.0004862285,0.0001672035,0.001830482],"genre_scores_gemma":[0.997092,0.0003674487,0.0004511999,0.000085763,0.000007479059,0.00002832345,0.0003380749,0.00002195913,0.001607754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003216422,"threshold_uncertainty_score":0.01076001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455669122216719,"score_gpt":0.2639512078453721,"score_spread":0.2493945166232049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}