{"id":"W3155982295","doi":"10.1101/2021.04.09.21255211","title":"Prefrontal glutamate neurotransmission in PTSD: A novel approach to estimate synaptic strength in vivo in humans","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Servier; Vistagen Therapeutics; Georgia Clinical and Translational Science Alliance; Genentech; Valeant Pharmaceuticals International; Yale Center for Clinical Investigation, Yale School of Medicine; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; National Alliance for Research on Schizophrenia and Depression; American Foundation for Suicide Prevention; Biogen; National Center for PTSD, U.S. Department of Veterans Affairs; Gilead Sciences; Yale University; Sanofi; Teva Pharmaceutical Industries; H. Lundbeck A/S; U.S. Department of Veterans Affairs","keywords":"Glutamatergic; Neurotransmission; Glutamate receptor; Neuroscience; Prefrontal cortex; Psychology; Medicine; Internal medicine; Receptor; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004665387,0.000423748,0.0003016821,0.0004159234,0.0002384439,0.0003651564,0.0002370322,0.0003873744,0.001533797],"category_scores_gemma":[0.0004716428,0.0002077373,0.0001532343,0.0002768085,0.0003711676,0.0002057754,0.0002845516,0.0004008069,0.0002526071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858947,"about_ca_system_score_gemma":0.0002059234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625437,"about_ca_topic_score_gemma":0.002967443,"domain_scores_codex":[0.9998106,0.00007322733,0.00001106387,0.00005067585,0.00004024414,0.00001414118],"domain_scores_gemma":[0.9998566,0.0000208459,0.00004744539,0.00002561856,0.00003129388,0.00001810752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003259897,0.0004847621,0.1910594,0.0006102936,0.0005528905,0.0004822656,0.0004797985,0.002106642,0.7216997,0.0006418506,0.001232051,0.07739042],"study_design_scores_gemma":[0.0001581043,0.00557769,0.8378091,0.00009427494,0.0003669409,0.003800235,0.0008111433,0.01434729,0.1304546,0.00159015,0.004912144,0.00007826833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602539,0.002290324,0.03344899,0.0001519128,0.00006311579,0.000198771,0.00100272,0.0000953329,0.002494976],"genre_scores_gemma":[0.9849706,0.0008718414,0.0128578,0.0001243432,0.00001591146,0.0001676578,0.0002061933,0.00001339499,0.0007722695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625437,"threshold_uncertainty_score":0.005131066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07553328099117021,"score_gpt":0.3654428378535168,"score_spread":0.2899095568623465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}