{"id":"W3156031737","doi":"10.1038/s41420-021-00458-4","title":"Necroptosis in ALS: a hot topic in-progress","year":2021,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Children's Hospital Foundation; Fondation de l'Hôpital de Montréal pour enfants; Government of Canada; Fondation des Etoiles; Région Auvergne-Rhône-Alpes","keywords":"Necroptosis; Biology; Programmed cell death; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470242,0.0001429737,0.0003281141,0.000132663,0.00002591539,0.00007863892,0.0001184911,0.0001095835,0.0003546707],"category_scores_gemma":[0.00007180755,0.0001211185,0.00009462158,0.0004541524,0.00005821045,0.0002280758,0.0001634527,0.0003370388,0.00007892397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158069,"about_ca_system_score_gemma":0.0002423987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002255321,"about_ca_topic_score_gemma":0.0001067112,"domain_scores_codex":[0.9984418,0.00008929946,0.0002792515,0.0003896271,0.0003343688,0.0004656551],"domain_scores_gemma":[0.9993398,0.00005869111,0.00003019093,0.0004015624,0.00004639558,0.0001234105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002062413,0.000707154,0.9529973,0.0002720451,0.0000208687,0.002111386,0.0003254024,0.00002120023,0.03824156,0.0003721979,0.0004197729,0.004304827],"study_design_scores_gemma":[0.001894285,0.00009639367,0.9757208,0.0003138899,0.00001375839,0.00001785887,0.0001206607,0.0001596228,0.01975142,0.0001939241,0.001565878,0.0001514817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895598,0.002184884,0.00002200922,0.00161335,0.0001061658,0.0002466432,0.000004236537,0.00001851526,0.006244447],"genre_scores_gemma":[0.9912836,0.000716702,0.0004054713,0.0004585259,0.00009503344,0.00005257541,0.00002761374,0.00002328691,0.006937209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02272348,"threshold_uncertainty_score":0.4939069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03237703271287622,"score_gpt":0.310243277854547,"score_spread":0.2778662451416707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}