{"id":"W3156071398","doi":"10.1161/hyp.68.suppl_1.p189","title":"Abstract P189: Disruption of <i>Cyp2c44</i> Increases Sodium Chloride Cotransporter Expression and Activity in the Distal Convoluted Tubule","year":2016,"lang":"en","type":"article","venue":"Hypertension","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"","keywords":"Distal convoluted tubule; Endocrinology; Internal medicine; Epoxygenase; Cotransporter; Epithelial sodium channel; Reabsorption; Chemistry; Renal physiology; Kidney; Sodium; Biology; Medicine; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738925,0.000578835,0.0006379584,0.0004611241,0.0005023082,0.0005614694,0.0004256295,0.000928748,0.01092558],"category_scores_gemma":[0.0001604437,0.0003545698,0.0009441265,0.0003717558,0.0007091661,0.0004026226,0.0003594598,0.002070833,0.003363454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000630311,"about_ca_system_score_gemma":0.0004826128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002973706,"about_ca_topic_score_gemma":0.002807539,"domain_scores_codex":[0.999495,0.00003856911,0.00005433247,0.0001509677,0.0001483171,0.0001127814],"domain_scores_gemma":[0.9996543,0.00002613141,0.0001209073,0.00002948964,0.00003708203,0.0001320647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005464514,0.0001512194,0.0005107762,0.000106564,0.00003131246,0.000412751,0.00003729189,0.0001112043,0.9935758,0.0004452998,0.001621669,0.002449737],"study_design_scores_gemma":[0.0001805908,0.0006360065,0.0170701,0.00002484977,0.0001146545,0.002054331,0.0001396523,0.001601509,0.9505512,0.0002314546,0.0273657,0.00002992688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517736,0.002618191,0.015115,0.002676673,0.001122323,0.0002337401,0.01425364,0.001489399,0.01071749],"genre_scores_gemma":[0.9479365,0.001734623,0.004311017,0.0009576625,0.0001702924,0.0002813661,0.007043364,0.0005882568,0.03697675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01092558,"threshold_uncertainty_score":0.03654975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515928062749438,"score_gpt":0.2427426175217157,"score_spread":0.2275833368942213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}