{"id":"W3156072316","doi":"10.3390/cancers13092020","title":"Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"Proteases; Mitochondrion; Biology; Proteasome; Cell biology; Autophagy; Oxidative phosphorylation; AAA proteins; Mitochondrial matrix; Cancer cell; Biochemistry; ATPase; Cancer; Apoptosis; Cytosol; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003582112,0.0007915236,0.001158055,0.001915186,0.0002500129,0.0009510376,0.0007142009,0.0008586318,0.003684445],"category_scores_gemma":[0.0003476233,0.0002684864,0.0004045607,0.001792007,0.000351599,0.00118309,0.000569903,0.001905103,0.002463978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005494242,"about_ca_system_score_gemma":0.0005947049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005166959,"about_ca_topic_score_gemma":0.001136002,"domain_scores_codex":[0.9998852,0.00001797112,0.00001428147,0.00001893465,0.00004687234,0.00001668017],"domain_scores_gemma":[0.9998647,0.00004581408,0.00002103607,0.00000449341,0.00004248293,0.00002153686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001143886,0.0001100786,0.0001203679,0.01529053,0.00007476445,0.0002773603,0.0000493296,0.0004118556,0.004984577,0.004178812,0.03237383,0.9420141],"study_design_scores_gemma":[0.00001931815,0.0001060652,0.000447471,0.001849709,0.00005421542,0.001123739,0.0000321941,0.00007582644,0.0007155419,0.001600709,0.9939625,0.00001279421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001215345,0.9985857,0.00009067095,0.0001742147,0.000145634,0.000003650758,0.00001727684,0.000007033773,0.0008542732],"genre_scores_gemma":[0.0004990136,0.9985011,0.0001290567,0.0001161275,0.00009114885,0.000004652034,0.00003121035,0.000001199602,0.0006265181],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003684445,"threshold_uncertainty_score":0.01232564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312117022927583,"score_gpt":0.3006046920580302,"score_spread":0.2693929897652719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}