{"id":"W3156072316","doi":"10.3390/cancers13092020","title":"Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"Proteases; Mitochondrion; Biology; Proteasome; Cell biology; Autophagy; Oxidative phosphorylation; AAA proteins; Mitochondrial matrix; Cancer cell; Biochemistry; ATPase; Cancer; Apoptosis; Cytosol; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009141308,0.0004633966,0.001011276,0.00006830882,0.0001339468,0.00005138648,0.0001770752,0.0009358682,0.0006067556],"category_scores_gemma":[0.0000898496,0.0003864743,0.0004415956,0.0001094902,0.0001457153,0.00000439274,0.0001875996,0.0003515038,0.00002670639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001808589,"about_ca_system_score_gemma":0.001044573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000346956,"about_ca_topic_score_gemma":0.00001507511,"domain_scores_codex":[0.9976989,0.0003009399,0.0004284911,0.001042047,0.000156568,0.000373066],"domain_scores_gemma":[0.9990414,0.00001336742,0.0002658519,0.0003999773,0.000101752,0.0001776896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004268105,0.00008389595,0.00004494952,0.003566536,0.001320193,0.0001127388,0.00002769758,0.0001101795,0.06542335,0.0001358141,0.04079522,0.8879526],"study_design_scores_gemma":[0.0005447876,0.0002650349,0.000003374377,0.0004547943,0.000364446,0.00009206963,0.0000134732,0.000001557516,0.0004971556,0.00000597932,0.9973158,0.0004414939],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002893289,0.991034,0.001340855,0.00002100077,0.005965699,0.0009102488,0.0002460421,0.00002731759,0.0001654664],"genre_scores_gemma":[0.00005395323,0.9911243,0.000176984,0.0002545915,0.004218215,0.0005575299,0.00134074,0.00005400922,0.002219646],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9565206,"threshold_uncertainty_score":0.9998587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312117022927583,"score_gpt":0.3006046920580302,"score_spread":0.2693929897652719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}