{"id":"W3156084043","doi":"10.1016/s0140-6736(21)00440-2","title":"IL17A/F nanobody sonelokimab in patients with plaque psoriasis: a multicentre, randomised, placebo-controlled, phase 2b study","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Plaque psoriasis; Placebo; Medicine; Dermatology; Psoriasis; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001386615,0.001557228,0.003223066,0.0003131796,0.0003577455,0.0009985337,0.0006386108,0.001749611,0.005502407],"category_scores_gemma":[0.001014508,0.000636942,0.001935571,0.0002958025,0.0008525187,0.0008728315,0.0003554186,0.002797964,0.001007072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004718319,"about_ca_system_score_gemma":0.0006605926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006956925,"about_ca_topic_score_gemma":0.001294129,"domain_scores_codex":[0.9995752,0.000175739,0.00002055827,0.00008900253,0.00004691597,0.00009244082],"domain_scores_gemma":[0.9994653,0.0001505424,0.0001041808,0.0000480884,0.00004985137,0.0001821881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9640217,0.005562142,0.0006384095,0.001003052,0.001577007,0.00006040741,0.00005533186,0.0002080113,0.006983493,0.00007844963,0.0009095691,0.01890234],"study_design_scores_gemma":[0.93938,0.0562841,0.002291272,0.00004208276,0.0006762277,0.00004471884,0.00003175413,0.0001475179,0.0003856363,0.00009951508,0.0006034657,0.00001364679],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838472,0.009790054,0.0007259717,0.0007656682,0.0007553347,0.00178861,0.0007639907,0.0001138169,0.00144937],"genre_scores_gemma":[0.9840595,0.005124696,0.001319934,0.001832891,0.0006439819,0.002051639,0.0008706869,0.00003629382,0.004060414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005502407,"threshold_uncertainty_score":0.01840734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441938214759182,"score_gpt":0.2506295868454478,"score_spread":0.236210204697856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}