{"id":"W3156084043","doi":"10.1016/s0140-6736(21)00440-2","title":"IL17A/F nanobody sonelokimab in patients with plaque psoriasis: a multicentre, randomised, placebo-controlled, phase 2b study","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Plaque psoriasis; Placebo; Medicine; Dermatology; Psoriasis; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005093872,0.0003144195,0.001076858,0.00007702993,0.0002112703,0.00003532098,0.0003252446,0.0001384554,0.0003732563],"category_scores_gemma":[0.0001524768,0.0001841968,0.0001262537,0.0002453784,0.00007340166,0.00008591119,0.00007608674,0.000254183,0.0002621228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005708164,"about_ca_system_score_gemma":0.00009507252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006619674,"about_ca_topic_score_gemma":0.0003938687,"domain_scores_codex":[0.9974967,0.001034847,0.0003971266,0.000426909,0.00008848884,0.0005559401],"domain_scores_gemma":[0.9985319,0.0004890324,0.0001716306,0.0006828265,0.00009648639,0.00002808176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7295586,0.01219402,0.2207641,0.00003147626,0.004409212,0.0002347906,0.007167287,0.00005129946,0.00296559,0.000096245,0.003802903,0.01872439],"study_design_scores_gemma":[0.9428602,0.0006469114,0.04827561,0.00005465037,0.0007365039,0.00001169747,0.001731466,0.00001050307,0.003019089,0.00002394874,0.002317353,0.0003121011],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940517,0.001683552,0.00001232625,0.0003523958,0.0006100323,0.002312443,0.0001040256,0.00006938645,0.000804121],"genre_scores_gemma":[0.9975591,0.00009798245,0.00006327311,0.0002000431,0.0001436525,0.0005030415,0.0002052215,0.00002710577,0.001200536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2133015,"threshold_uncertainty_score":0.751133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441938214759182,"score_gpt":0.2506295868454478,"score_spread":0.236210204697856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}