{"id":"W3156096663","doi":"10.1128/aac.00390-21","title":"Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Foscarnet; Herpes simplex virus; Virology; DNA polymerase; Human cytomegalovirus; Biology; Polymerase; DNA; Gene; Virus; Cytomegalovirus; Alphaherpesvirinae; Herpesviridae; Molecular biology; Ganciclovir; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157916,0.0003434235,0.0002321817,0.0001518706,0.00008323815,0.0002507061,0.0001630105,0.0002332043,0.002800229],"category_scores_gemma":[0.0002732281,0.0001101972,0.0001828815,0.0001061319,0.0002561295,0.0001624158,0.0001276011,0.0003078132,0.0002985029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620551,"about_ca_system_score_gemma":0.0001704625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004718308,"about_ca_topic_score_gemma":0.0005393871,"domain_scores_codex":[0.9998499,0.00004833694,0.00001877016,0.00002252288,0.00002983609,0.00003074854],"domain_scores_gemma":[0.9998155,0.00006271488,0.00004615304,0.00001262044,0.00001192632,0.0000511101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001854858,0.0002118311,0.001270018,0.00004860762,0.00005126371,0.0001977958,0.00002344632,0.000566762,0.9924064,0.0001226619,0.00005551731,0.003190844],"study_design_scores_gemma":[0.0001213498,0.004481177,0.01738331,0.00002107785,0.0001634431,0.0008314946,0.00009569946,0.003323847,0.9711165,0.0001074941,0.002336926,0.00001772786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988532,0.0003280208,0.0002047446,0.00002199041,0.00001951753,0.000009443048,0.00006413506,0.000009789838,0.0004891393],"genre_scores_gemma":[0.9990785,0.0001232883,0.000244924,0.00002102851,0.000004707524,0.000004808902,0.000097852,0.000007340398,0.0004174455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002800229,"threshold_uncertainty_score":0.009367704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03060855710407347,"score_gpt":0.3345903031008876,"score_spread":0.3039817459968141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}