{"id":"W3156101683","doi":"","title":"Trabecular meshwork fibrosis and PI3-kinase isoforms as drug targets","year":2019,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Skin Diseases and Diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Trabecular meshwork; Gene isoform; Fibrosis; Drug; Focus (optics); Kinase; Cell biology; Medicine; Pharmacology; Chemistry; Internal medicine; Ophthalmology; Biology; Glaucoma; Physics; Biochemistry; Gene; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003922734,0.0003184407,0.0003925656,0.0004546694,0.0002794091,0.000884209,0.0002990085,0.0005579604,0.002514077],"category_scores_gemma":[0.0002491567,0.0001236558,0.0004225588,0.0005696592,0.0002570724,0.0004148795,0.0003160227,0.001049809,0.0004002929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006598684,"about_ca_system_score_gemma":0.0005216293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001040514,"about_ca_topic_score_gemma":0.003441108,"domain_scores_codex":[0.9998692,0.00002676233,0.000009637491,0.00001368917,0.00003806213,0.00004267625],"domain_scores_gemma":[0.9998833,0.00002061515,0.00004405034,0.000008800033,0.00001999783,0.00002313341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0073056,0.001381042,0.01006943,0.00230273,0.0005006102,0.002088679,0.0001446324,0.002968248,0.211509,0.01784748,0.02018612,0.7236964],"study_design_scores_gemma":[0.008019711,0.01257617,0.08266181,0.001507504,0.001460275,0.009356769,0.0008031899,0.01338614,0.274457,0.02065608,0.57496,0.0001553043],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3526456,0.5832055,0.005190234,0.01128433,0.001163836,0.0001737033,0.0006558818,0.0002321842,0.04544872],"genre_scores_gemma":[0.8157259,0.1670329,0.003018958,0.001558041,0.0004408644,0.000117172,0.0004837772,0.00002410154,0.01159821],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002514077,"threshold_uncertainty_score":0.008410394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517915789528945,"score_gpt":0.3110609177751921,"score_spread":0.2958817598799026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}