{"id":"W3156128630","doi":"10.1097/01.hjh.0000747364.27941.06","title":"ALDOSTERONE CONTRIBUTES TO SYSTOLIC BLOOD PRESSURE ELEVATION DURING REST TIME IN MALE MICE INDUCIBLY OVEREXPRESSING HUMAN ENDOTHELIN-1 IN ENDOTHELIUM","year":2021,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Aldosterone; Endocrinology; Internal medicine; Mineralocorticoid receptor; Medicine; Aldosterone synthase; Endothelin 1; Endothelin receptor; Mineralocorticoid; Spironolactone; Receptor; Blood pressure; Renin–angiotensin system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401281,0.0007595074,0.0006220058,0.0006592096,0.0002446554,0.0005083164,0.0003569831,0.0004238399,0.002555211],"category_scores_gemma":[0.0002240523,0.0004549436,0.0005978403,0.0002329692,0.0004762105,0.0004139496,0.0002783628,0.001562818,0.0006127009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467341,"about_ca_system_score_gemma":0.0001633908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816721,"about_ca_topic_score_gemma":0.0005384266,"domain_scores_codex":[0.9996501,0.0000504265,0.00003860357,0.00009102628,0.00008964522,0.00008020288],"domain_scores_gemma":[0.9992486,0.0000426708,0.0003120596,0.00005514586,0.00003774267,0.00030379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004679612,0.00008359249,0.0004851516,0.00001805185,0.000006682008,0.0001109199,0.00001488569,0.00001065722,0.9981917,0.00002402569,0.00002520369,0.0005611387],"study_design_scores_gemma":[0.0003128351,0.003692032,0.118667,0.00003497479,0.0002184039,0.00290246,0.0002134756,0.001100223,0.8706818,0.0001391977,0.002001453,0.00003625473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971807,0.0007251007,0.001154367,0.0001191631,0.00003880935,0.00001437811,0.0002752548,0.00008309687,0.0004092883],"genre_scores_gemma":[0.9934341,0.000875429,0.00129761,0.0001199561,0.00006845812,0.00007848747,0.000588988,0.00006603939,0.003470927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002555211,"threshold_uncertainty_score":0.008548081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02419356358204762,"score_gpt":0.2571465845309643,"score_spread":0.2329530209489167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}