{"id":"W3156173951","doi":"10.1212/wnl.94.15_supplement.2663","title":"Novel Receptor Activity Mapping of Methysergide and its Metabolite, Methylergometrine, Provides a Mechanistic Rationale for both the Clinically Observed Efficacy and Risk of Fibrosis in Patients with Migraine (2663)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Migraine; Methysergide; Metabolite; Medicine; Fibrosis; Internal medicine; Receptor; Pharmacology; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003875378,0.0002323434,0.0002990507,0.0002151508,0.0001483535,0.0002988008,0.0001851744,0.0004077839,0.002858575],"category_scores_gemma":[0.0004142275,0.0001050978,0.0002337622,0.0001369368,0.0003132405,0.0002280785,0.00010318,0.0004457021,0.0003533099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531477,"about_ca_system_score_gemma":0.0001130337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006556876,"about_ca_topic_score_gemma":0.001135871,"domain_scores_codex":[0.9998719,0.000065673,0.00000704589,0.00002028435,0.00001399925,0.00002119858],"domain_scores_gemma":[0.9998286,0.00006850775,0.00004136148,0.00002043699,0.00001512882,0.0000259034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005031195,0.0003810566,0.02408083,0.0001207876,0.00009388645,0.0004969751,0.0001118255,0.0001815846,0.9510232,0.000512104,0.0001666085,0.01779999],"study_design_scores_gemma":[0.001343982,0.02556766,0.3322835,0.00004643752,0.0003451863,0.006384995,0.0004384572,0.002549125,0.6246392,0.000766748,0.005601338,0.00003340523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990813,0.002744492,0.003907623,0.0001512879,0.0000306998,0.00006480247,0.0001626447,0.00002192788,0.002103642],"genre_scores_gemma":[0.996754,0.000409143,0.001922054,0.00006907242,0.00002355611,0.00003554408,0.0001109421,0.000004012193,0.0006715767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002858575,"threshold_uncertainty_score":0.00956291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06260576006749508,"score_gpt":0.283166167601383,"score_spread":0.2205604075338879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}