{"id":"W3156260088","doi":"10.21203/rs.3.rs-379923/v1","title":"Biological functions of Lacticaseibacillus rhamnosus JB-1 membrane vesicles: lipoteichoic acid, immune activity, and gut epithelial endocytosis","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; McMaster University","keywords":"Lipoteichoic acid; Endocytosis; Lactobacillus rhamnosus; Internalization; Cell biology; TLR2; Biology; Bacteria; Immune system; Microbiology; Receptor; Biochemistry; Lactobacillus; TLR4; Immunology; Signal transduction; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958382,0.0002816562,0.0001552559,0.0001873006,0.0001507172,0.0003640967,0.0001103749,0.0003554812,0.0008856702],"category_scores_gemma":[0.000124798,0.00006071418,0.0001795328,0.00009629285,0.0002000438,0.0002079295,0.0001914202,0.0002162599,0.0004003681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174247,"about_ca_system_score_gemma":0.000142307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005823358,"about_ca_topic_score_gemma":0.0003060592,"domain_scores_codex":[0.9999448,0.00001311052,0.000003358266,0.000008056998,0.0000117272,0.00001902631],"domain_scores_gemma":[0.999951,0.00001104328,0.00001060204,0.000003356641,0.000007663741,0.00001635989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002199973,0.00001429271,0.0004929614,0.00006408982,0.000004565402,0.0001054445,0.00001633433,0.00005085946,0.9977755,0.0002286659,0.00002398212,0.001003307],"study_design_scores_gemma":[0.0000167066,0.0001660293,0.01098506,0.00001579118,0.00001403282,0.0005185216,0.00007650223,0.0009062345,0.9848578,0.0002703704,0.002167684,0.000005269469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882157,0.007167422,0.001726943,0.0002395521,0.0000366694,0.00001359484,0.0001863336,0.00002650311,0.002387271],"genre_scores_gemma":[0.995099,0.001264386,0.0007526362,0.00003148952,0.00001069103,0.000007198593,0.0002363884,0.000009171551,0.002589108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008856702,"threshold_uncertainty_score":0.002962828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06577766667392645,"score_gpt":0.3482692223524378,"score_spread":0.2824915556785114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}