{"id":"W3156298789","doi":"10.3390/ijms22084048","title":"Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Universidad de Málaga","keywords":"Osteopontin; IGFBP3; Bone remodeling; Endocrinology; Internal medicine; Osteocalcin; Bone resorption; Bone mineral; Resorption; Chemistry; Biology; Osteoporosis; Growth factor; Medicine; Alkaline phosphatase; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912875,0.0008049687,0.0003728321,0.0008018131,0.00015833,0.0003441295,0.0003065004,0.0004882626,0.003003209],"category_scores_gemma":[0.000138856,0.0004379045,0.0003634,0.0002196405,0.0004651906,0.0002510187,0.000304534,0.001236573,0.0005785738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002343542,"about_ca_system_score_gemma":0.0002175718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665022,"about_ca_topic_score_gemma":0.001058232,"domain_scores_codex":[0.9997397,0.00003109775,0.00002730572,0.00008298492,0.00006885763,0.00005002434],"domain_scores_gemma":[0.9995497,0.0000323254,0.0002071856,0.00003089663,0.00002807012,0.0001517487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002244521,0.00003650474,0.0003492489,0.00002208271,0.000006133345,0.00008649308,0.0000127394,0.00001737199,0.9986209,0.0000232572,0.00002821078,0.0005726551],"study_design_scores_gemma":[0.0001055208,0.0009733886,0.02910381,0.00002206139,0.0000600563,0.001383908,0.0001166016,0.0005739908,0.9641941,0.000103391,0.003347064,0.00001616712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932907,0.001316875,0.00251642,0.0001483925,0.00004268546,0.00002782946,0.001531427,0.0002119612,0.0009137178],"genre_scores_gemma":[0.9816164,0.001413508,0.003884345,0.0001995537,0.00003535231,0.0001729726,0.001962922,0.0002120995,0.01050295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003003209,"threshold_uncertainty_score":0.01004672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963413492298351,"score_gpt":0.2646890292805646,"score_spread":0.2450548943575811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}