{"id":"W3156311624","doi":"10.3390/antibiotics10040433","title":"The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Dihydrofolate reductase; Context (archaeology); Trimethoprim; Public health; Biology; Microbiology; Genetics; Gene; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406518,0.0001799403,0.000304464,0.0007331008,0.0002197528,0.0004624753,0.0001224058,0.0003773229,0.001062321],"category_scores_gemma":[0.0005609834,0.00009778009,0.000183372,0.0006942794,0.0002230418,0.0002318449,0.0002328548,0.0002694771,0.0004949117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691923,"about_ca_system_score_gemma":0.0002802318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001668872,"about_ca_topic_score_gemma":0.002374008,"domain_scores_codex":[0.9997699,0.00004001033,0.00001596414,0.00007297901,0.00006038857,0.00004079752],"domain_scores_gemma":[0.9995671,0.0001173414,0.0001821893,0.00004101135,0.00005258794,0.00003974706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001673147,0.00003483489,0.05514526,0.0002841494,0.00003167575,0.0005488559,0.0002077448,0.0001520774,0.9256091,0.0002771061,0.0001304566,0.0174115],"study_design_scores_gemma":[0.000008457017,0.0003620663,0.7945199,0.0001321614,0.0001293574,0.004354035,0.001117666,0.0009529897,0.1842112,0.000760086,0.0134234,0.000028658],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915484,0.003056928,0.002223588,0.0002375463,0.00001172579,0.00001122102,0.001895705,0.00004448252,0.0009704258],"genre_scores_gemma":[0.9940346,0.001190195,0.002076229,0.00008515215,0.00001688289,0.000005782664,0.002161537,0.000007743331,0.0004219146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668872,"threshold_uncertainty_score":0.003553867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532411819389601,"score_gpt":0.3204346952921784,"score_spread":0.2851105770982824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}