{"id":"W3156311624","doi":"10.3390/antibiotics10040433","title":"The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Dihydrofolate reductase; Context (archaeology); Trimethoprim; Public health; Biology; Microbiology; Genetics; Gene; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004925024,0.000193736,0.0002750265,0.00004525041,0.0002567659,0.00009292867,0.0003932898,0.0001457217,0.00001759582],"category_scores_gemma":[0.0002318924,0.0001466995,0.0001409612,0.0002149328,0.0001622921,0.000006064808,0.0003415055,0.0001273665,0.000007346838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000334141,"about_ca_system_score_gemma":0.0005060058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009664712,"about_ca_topic_score_gemma":0.0001268793,"domain_scores_codex":[0.9980096,0.0002778194,0.0004124208,0.0005082976,0.0002384344,0.0005534035],"domain_scores_gemma":[0.9985144,0.00003238767,0.0001215224,0.0007737821,0.0002320402,0.0003258854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001657274,0.0001357977,0.00005853206,0.00002962754,0.00009357473,0.00001025808,0.00008507338,0.000001741052,0.9909355,0.001235195,0.001686698,0.005562268],"study_design_scores_gemma":[0.0003757733,0.0004304221,0.0003674026,0.00001802225,0.00001166488,0.00001112842,0.0001687155,0.00001040416,0.8876594,0.00005486237,0.1107285,0.0001637432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875367,0.002724598,0.0004291485,0.008578176,0.0002631354,0.0002218751,0.00008560762,0.00001310686,0.0001475954],"genre_scores_gemma":[0.9953362,0.001588253,0.001286778,0.0005766993,0.0002715666,9.276135e-7,0.0003808913,0.00003496608,0.000523672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1090418,"threshold_uncertainty_score":0.5982233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532411819389601,"score_gpt":0.3204346952921784,"score_spread":0.2851105770982824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}