{"id":"W3156389344","doi":"10.7554/elife.65962","title":"SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Volkswagen Foundation; National Heart, Lung, and Blood Institute; Longer Life Foundation; Human Frontier Science Program; Boston University; SENSHIN Medical Research Foundation; Uehara Memorial Foundation; Burroughs Wellcome Fund; Office of the Dean for Research, Princeton University; Japan Society for the Promotion of Science; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Syncytium; Cell fusion; Biology; Lipid bilayer fusion; Viral entry; Cell biology; Fusion mechanism; Intracellular; Viral replication; Cell; Coronavirus; Virology; Viral envelope; Cell culture; Virus; Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602503,0.0001161751,0.0002217419,0.00006207598,0.00008566354,0.00005658181,0.00006520638,0.0001283705,0.000004622346],"category_scores_gemma":[0.0004562013,0.00009475335,0.0000807251,0.00009941222,0.00006938799,0.0001699808,0.00008351493,0.0001645832,0.00004728273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004971095,"about_ca_system_score_gemma":0.0001065842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008348258,"about_ca_topic_score_gemma":0.00001211952,"domain_scores_codex":[0.9988734,0.00004998074,0.0002302292,0.0002565899,0.0003026185,0.0002872425],"domain_scores_gemma":[0.999458,0.00009058439,0.00004148063,0.0002265439,0.0001523732,0.00003106622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003141159,0.0001348871,0.01294482,0.0002397237,0.00002738057,0.0001708172,0.0003523196,5.226529e-8,0.9671218,0.0003635615,0.00472173,0.01360884],"study_design_scores_gemma":[0.002191263,0.0003157726,0.01412928,0.00007934849,0.00003385697,0.0002319351,0.0001334541,0.0005457019,0.8711481,0.0002423554,0.1108349,0.0001140292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945334,0.0007580458,0.001595014,0.001082543,0.00009985598,0.0003522985,0.00001392915,0.0000650214,0.001499905],"genre_scores_gemma":[0.9422984,0.00002892304,0.0006255844,0.05660293,0.0002772119,0.00007343061,0.00002007004,0.00001545033,0.00005800902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1061132,"threshold_uncertainty_score":0.386393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06433346200209393,"score_gpt":0.3711560398145306,"score_spread":0.3068225778124367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}