{"id":"W3156389344","doi":"10.7554/elife.65962","title":"SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Volkswagen Foundation; National Heart, Lung, and Blood Institute; Longer Life Foundation; Human Frontier Science Program; Boston University; SENSHIN Medical Research Foundation; Uehara Memorial Foundation; Burroughs Wellcome Fund; Office of the Dean for Research, Princeton University; Japan Society for the Promotion of Science; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Syncytium; Cell fusion; Biology; Lipid bilayer fusion; Viral entry; Cell biology; Fusion mechanism; Intracellular; Viral replication; Cell; Coronavirus; Virology; Viral envelope; Cell culture; Virus; Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002530895,0.0002834733,0.00046132,0.0003100132,0.0002830772,0.0004402792,0.0001491901,0.0003777322,0.001026183],"category_scores_gemma":[0.0002614961,0.0001590642,0.0003731188,0.0002633398,0.0002385313,0.0002354077,0.000341651,0.0003067977,0.000308416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005137488,"about_ca_system_score_gemma":0.0004016093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001667664,"about_ca_topic_score_gemma":0.004083155,"domain_scores_codex":[0.9996502,0.00004565946,0.00003231784,0.00004465892,0.0001698917,0.00005720844],"domain_scores_gemma":[0.9998714,0.00002833563,0.00003325419,0.00001652169,0.00002805421,0.00002244305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005644817,0.00001609517,0.0005826119,0.00001445045,0.000003161542,0.00005924333,0.000008481631,0.00003599072,0.9985695,0.00005829449,0.00001741928,0.0005783036],"study_design_scores_gemma":[0.0000166646,0.0003110955,0.02223327,0.000007173989,0.00001081203,0.0006999849,0.00006385295,0.001042336,0.9741672,0.00008357003,0.001357368,0.000006768355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937863,0.001067869,0.002434418,0.00008961838,0.00001262956,0.00006824001,0.0004729428,0.00003723217,0.002030723],"genre_scores_gemma":[0.9949129,0.0005706417,0.002395229,0.00006011991,0.000004537104,0.00004554286,0.0006682159,0.00000900814,0.001333881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667664,"threshold_uncertainty_score":0.003727496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06433346200209393,"score_gpt":0.3711560398145306,"score_spread":0.3068225778124367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}