{"id":"W3156394540","doi":"10.3389/fimmu.2021.624324","title":"Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Tumor microenvironment; Immune system; Amino acid transporter; mTORC1; Cancer cell; Immunotherapy; Biology; Transporter; Cytotoxic T cell; Cell biology; Effector; Glutamine; Cancer immunotherapy; Biochemistry; Chemistry; Amino acid; Cancer; Immunology; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613607,0.0002637974,0.0003062399,0.0002050026,0.0001133311,0.0003051281,0.0002115378,0.0004494037,0.0009458097],"category_scores_gemma":[0.00007037738,0.0000967765,0.0003393087,0.0001528894,0.0002069863,0.0003108976,0.0002016809,0.000483001,0.0001839936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397566,"about_ca_system_score_gemma":0.0003347844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006389091,"about_ca_topic_score_gemma":0.001622602,"domain_scores_codex":[0.9999274,0.0000136789,0.000004545019,0.00001113547,0.00001960429,0.00002369497],"domain_scores_gemma":[0.9999639,0.000004083458,0.000009192574,0.00000252088,0.000008170978,0.00001217003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001646102,0.00008496801,0.0003365132,0.000380249,0.00003333887,0.0002057989,0.00002877529,0.0005114024,0.9757942,0.001200356,0.0008294557,0.02043034],"study_design_scores_gemma":[0.0002388044,0.001883623,0.005343137,0.0000871905,0.000280683,0.001164144,0.0001318748,0.009746438,0.9080017,0.001007122,0.07207454,0.00004077925],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9013205,0.04846946,0.03846475,0.002922371,0.000445159,0.0002583394,0.00033956,0.0006849655,0.007094892],"genre_scores_gemma":[0.9685482,0.01330299,0.01351485,0.0007113332,0.00006225128,0.0001027559,0.0003165469,0.00003446864,0.003406556],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0009458097,"threshold_uncertainty_score":0.003164053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451697237706566,"score_gpt":0.2484589811515279,"score_spread":0.2339420087744622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}